Recent advances in BLV research
| Autor: | Nicolas Gillet, Pierre-Yves Barez, Bernard Staumont, Luc Willems, Jean-Rock Jacques, Alexandre Carpentier, Michal Reichert, Nathalie Renotte, Hélène Gazon, Alix de Brogniez, Sathyanarayana Neelature Sriramareddy, Gerónimo Gutiérrez, Srikanth Perike, Katrina Trono, Malik Hamaidia |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Biomedical Research
Respuesta Inmunológica Transgene viruses Tax lcsh:QR1-502 BLV Lymphoproliferative disorders Disease Review Enfermedades de los Animales lcsh:Microbiology Virus Animal Diseases Immune system HDAC vaccine Virology Virus Leucemia Bovina medicine Leukemia Virus Bovine Animals Humans Immune Response Human T-lymphotropic virus 1 Vaccines Bovine leukemia virus biology microRNA Vacuna biology.organism_classification medicine.disease Deltaretrovirus Disease Models Animal Infectious Diseases HTLV-1 Immunology Host-Pathogen Interactions Ganado Bovino Bovine Leukaemia Virus Cattle |
| Zdroj: | Viruses 7 (11) : 6080-6088 (November 2015) INTA Digital (INTA) Instituto Nacional de Tecnología Agropecuaria instacron:INTA Viruses Viruses, Vol 7, Iss 11, Pp 6080-6088 (2015) |
| Popis: | Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies. Instituto de Virología Fil: Barez, Pierre-Yves. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: de Brogniez, Alix. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Carpentier, Alexandre. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Gazon, Hélène. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Gillet, Nicolas. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Gutierrez, Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Hamaidia, Malik. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Jacques, Jean-Rock. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Perike, Srikanth. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Sriramareddy, Sathya Neelature. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Renotte, Nathalie. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Staumont, Bernard. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica Fil: Reichert, Michal. National Veterinary Research Institute; Polonia Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica |
| Databáze: | OpenAIRE |
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