Young age at first pregnancy does protect against early onset breast cancer in BRCA1 and BRCA2 mutation carriers
| Autor: | S. Howel, Emma R. Woodward, Fiona Lalloo, D. G. R. Evans, Elaine F. Harkness, Anthony Howell |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Cancer Research medicine.medical_specialty endocrine system diseases Epidemiology Population Breast Neoplasms Risk Assessment 03 medical and health sciences Young Adult 0302 clinical medicine Breast cancer Pregnancy Medicine Humans Genetic Predisposition to Disease Young adult Age of Onset education skin and connective tissue diseases Age at first pregnancy BRCA2 Protein education.field_of_study business.industry Obstetrics BRCA1 Protein Incidence (epidemiology) Age Factors Odds ratio Middle Aged medicine.disease BRCA1 BRCA2 030104 developmental biology Oncology England 030220 oncology & carcinogenesis Mutation Female Age of onset business Risk assessment |
| Zdroj: | Breast Cancer Research and Treatment Evans, D, Harkness, E, Howell, S, Woodward, E, Howell, A & Lalloo, F 2018, ' Young age at first pregnancy does protect against early onset breast cancer in BRCA1 and BRCA2 mutation carriers ', Breast Cancer Research and Treatment, vol. 167, no. 3, pp. 779-785 . https://doi.org/10.1007/s10549-017-4557-1 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-017-4557-1 |
| Popis: | Purpose Previous research assessing the impact of pregnancy and age at first pregnancy on breast cancer risk in BRCA1 and BRCA2 mutation carriers has produced conflicting results, with some studies showing an increased risk following early first pregnancy in contrast to the reduced risk in the general population of women. The present study addresses these inconsistencies. Methods Female BRCA1 and BRCA2 carriers from North West England were assessed for breast cancer incidence prior to 50 years of age comparing those with an early first full-term pregnancy ( |
| Databáze: | OpenAIRE |
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