Conioidines A and B, novel DNA-interacting pyrrolidines from Chamaesaracha conioides
| Autor: | Mark E. Hemling, John Westley, Priscilla Offen, Charles W. DeBrosse, MacKenzie-LoCasto L, George Wai-Kin Chan, Berry D |
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| Rok vydání: | 1993 |
| Předmět: |
Pyrrolidines
Stereochemistry Cell Survival Pharmaceutical Science Biology Pharmacognosy Solanaceous Alkaloids Pyrrolidine KB Cells Analytical Chemistry Hydrolysis chemistry.chemical_compound Drug Discovery medicine Animals Humans Doxorubicin Cytotoxicity Pharmacology Plants Medicinal Organic Chemistry DNA Neoplasm biology.organism_classification Antineoplastic Agents Phytogenic In vitro Complementary and alternative medicine Biochemistry chemistry Molecular Medicine Cattle DNA Solanaceae medicine.drug |
| Zdroj: | Journal of natural products. 56(5) |
| ISSN: | 0163-3864 |
| Popis: | Two novel pyrrolidine compounds, conioidines A [1] and B [2], have been isolated from the Texas plant, Chamaesaracha conioides (Solanaceae). Their structures were determined by spectroscopic methods and hydrolysis studies. Both natural products, like doxorubicin, showed DNA-specific KB cell cytotoxicity. Dose-response data indicated a Kd value of 2.8 microM for binding of conioidine A [1] to calf thymus DNA. |
| Databáze: | OpenAIRE |
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