Induction of a Hardening Phenomenon and Quantitative Changes of Ceramides in Stratum Corneum
| Autor: | Soo Ick Cho, Jin Hye Kim, Kyeong Il Kim, Chun Wook Park, Hye One Kim, Sook Young Park, Hee Jin Cho, Cheol Heon Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Ceramide
medicine.medical_specialty Erythema Human skin Dermatology macromolecular substances medicine.disease_cause Ceramides chemistry.chemical_compound Internal medicine Stratum corneum Medicine Irritation contact dermatitis Transepidermal water loss integumentary system business.industry Endocrinology medicine.anatomical_structure chemistry Distilled water Hardening (metallurgy) Hardening phenomenon Original Article Irritation medicine.symptom business |
| Zdroj: | Annals of Dermatology |
| ISSN: | 2005-3894 1013-9087 |
| Popis: | Background Hardening phenomenon of human skin after repeated exposure to the irritants is well-known, but the precise mechanism remains elusive. Objective To modify the previous experimental model of hardening phenomenon by repeated applications of two different concentrations of sodium lauryl sulfate (SLS) solutions to Korean healthy volunteers and to investigate the quantitative changes of ceramides in stratum corneum before and after chronic repeated irritation. Methods Eight hundred microliters of distilled water containing 0.1% and 2% SLS was applied for 10 minutes on the forearm of 41 healthy volunteers for 3 weeks. After an intervening 3-week rest, 24-hour patch tests with 1% SLS were conducted on previously irritated sites. Transepidermal water loss (TEWL), erythema index and quantity of ceramide were measured in the stratum corneum before and after irritation. Results TEWL values on the sites preirritated with 2% SLS were lower than those with 0.1% SLS. Hardening phenomenon occurred in 24 volunteers at day 44. The changes in ceramide levels were not significantly higher in the hardened skin than in the non-hardened skin. Conclusion Repetitive stimulation with a higher concentration of SLS can more easily trigger skin hardening. |
| Databáze: | OpenAIRE |
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