Micelle-like nanoparticles of block copolymer poly(ethylene oxide)-block-poly(methacrylic acid) incorporating fluorescently substituted metallacarboranes designed as HIV protease inhibitor interaction probes
| Autor: | Pavel Matejicek, Petr Cigler, Mariusz Uchman, Karel Procházka, Bohumír Grüner |
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| Rok vydání: | 2010 |
| Předmět: |
Boron Compounds
Poly(methacrylic acid) Polyesters Methacrylate Micelle Fluorescence Polyethylene Glycols Biomaterials chemistry.chemical_compound Colloid and Surface Chemistry Dynamic light scattering Polymer chemistry Copolymer Moiety Humans Micelles Ethylene oxide Chemistry HIV Protease Inhibitors Surfaces Coatings and Films Electronic Optical and Magnetic Materials Methacrylic acid Metals Molecular Probes Methacrylates Nanoparticles |
| Zdroj: | Journal of colloid and interface science. 348(1) |
| ISSN: | 1095-7103 |
| Popis: | We prepared nanoparticles differing in morphology from double-hydrophilic block copolymer poly(ethylene oxide)-block-poly(methacrylic acid), PEO-PMA, and two types of fluorescein-[3-cobalt(III) bis(1,2-dicarbollide)] conjugates, GB176 and GB179, in alkaline buffer. GB176 molecule consists of fluorescein attached to the metallacarborane anion. In GB179 molecule, the fluorescein moiety connects two metallacarborane anions. The self-assembly is based on the unusual interaction of metallacarborane clusters with PEO blocks which form insoluble micellar cores. The GB176 containing nanoparticles are loose and irregular, while the GB179 ones are rigid and spherical. The structure of nanoparticles depends to some extent on a procedure of preparation. The micelles were studied by static and dynamic light scattering, fluorometry and atomic force microscopy. Since the metallacarborane conjugates act as potent inhibitors of HIV protease, the presented system is important from the point of view of drug delivery. |
| Databáze: | OpenAIRE |
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