PHARMACOKINETICS AND NEPHROTOXICITY OF CYCLOSPORINE IN RENAL TRANSPLANT RECIPIENTS
| Autor: | A. J. Moolenaar, L. A. Van Es, L. C. Paul, D. D. Breimer, F. C. Henny, C H Kleinbloesem |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Renal function Cyclosporins Pharmacology Kidney Kidney Function Tests Nephrotoxicity Pharmacokinetics medicine Humans Kidney transplantation Transplantation business.industry Area under the curve Middle Aged medicine.disease Kidney Transplantation Discontinuation Kinetics medicine.anatomical_structure Female business |
| Zdroj: | Transplantation. 40:261-265 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-198509000-00008 |
| Popis: | Pharmacokinetics of Cyclosporine (CsA) were studied in 14 renal transplant patients during a three-month period of treatment. At 3 and 15 days after transplantation 12-hr blood level studies of the drug were performed to calculate the elimination half-life, area under the curve (AUC), and total blood clearance; trough levels were measured twice weekly. In 9 patients terminal half-lives could be calculated after discontinuation of CsA treatment. In the course of CsA treatment, prolongation of half-life was found in most cases, with a significant decrease in clearance (46 +/- 17 L/hr on day 3 versus 28 +/- 10 L/hr on day 15). This resulted in a continuous increase in the CsA blood level. The terminal half-life varied considerably among the patients (24-93 hr) and did not correlate with other pharmacokinetic parameters. A good correlation (r = 0.9589) was observed between CsA trough levels before discontinuation of CsA and the increment in renal function two weeks after conversion to azathioprine. This indicates that short-term CsA treatment induces a dose-dependent reversible nephrotoxic effect in renal transplant recipients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|