Excretion of antibiotics in bile
| Autor: | Patricia M. Harrison, G. T. Stewart |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
medicine.drug_class
Paromomycin Antibiotics Penicillanic Acid Penicillins Benzylpenicillin Microbiology Excretion medicine Animals Bile Antibiotics Antitubercular Chemistry Chloramphenicol Biological Transport Neomycin Penicillin G General Medicine Articles Anti-Bacterial Agents Body Fluids Rats Penicillin Streptomycin Ampicillin medicine.drug |
| Zdroj: | British journal of pharmacology and chemotherapy. 17 |
| ISSN: | 0366-0826 |
| Popis: | The excretion of antibiotics in the bile of rats has been studied. Penicillins, including derivatives of 6-aminopenicillanic acid, are rapidly excreted, reabsorbed and re-excreted, in high concentration, whereas streptomycin, neomycin, paramomycin and chloramphenicol reach lower levels in the bile than in the plasma. p-Aminobenzylpenicillin and D(—)-6-(α-amino-α-phenylacetamido)penicillanic acid, both of which are bactericidal to Salmonellae and other coliforms, produce higher concentrations in the bile than benzylpenicillin (penicillin G). This may be of therapeutic importance. |
| Databáze: | OpenAIRE |
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