Epstein-Barr Virus-associated Intracranial Leiomyosarcoma in an HIV-positive Adolescent
| Autor: | Peter L. Havens, James F. Southern, Selim Firat, Sachin Jogal, Sweta Gupta |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Leiomyosarcoma
Epstein-Barr Virus Infections Herpesvirus 4 Human Pathology medicine.medical_specialty Stereotactic biopsy Adolescent medicine.medical_treatment Neutropenia Intracranial Neoplasm medicine.disease_cause Virus hemic and lymphatic diseases HIV Seropositivity medicine Humans In Situ Hybridization medicine.diagnostic_test Brain Neoplasms business.industry Hematology medicine.disease Magnetic Resonance Imaging Virology Epstein–Barr virus Gemcitabine Radiation therapy Treatment Outcome Oncology Pediatrics Perinatology and Child Health HIV-1 RNA Viral Female business medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 32:e144-e147 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/mph.0b013e3181c80bf3 |
| Popis: | SUMMARY A 17-year-old African American female with human immunodeficiency virus infection presented with an unresectable intracranial neoplasm with mass effect upon the brainstem. Stereotactic biopsy revealed an Epstein-Barr virus (EBV)-associated leiomyosarcoma. Radiation therapy and gemcitabine were used to shrink the mass with the aim to make it surgically resectable. Prolonged neutropenia and recurrent skin infections led to the discontinuation of gemcitabine. The mass stabilized after radiation therapy and has decreased in size in 15 months of follow-up. EBV has been demonstrated in most smooth muscle tumors associated with acquired immunodeficiency syndrome and other immunocompromised states. This is the first documented case of an EBV-positive intracranial leiomyosarcoma in a pediatric human immunodeficiency virus patient. |
| Databáze: | OpenAIRE |
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