Absence of Tissue Ingrowth through the Textile Fabric in a Series of Explanted Clinic Stent-Grafts
| Autor: | Jürgen Koebke, Georgi R. Marinov, Dangheng Wei, Gregory Samis, Lu Wang, Jing Lin, Tieying Yin, Mark Nutley, Yvan Douville, Jutta Knifka, Thien How, Robert Guidoin, Nathalie Gilbert, Guy Dionne, Bin Li, Ze Zhang |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Biocompatibility Polyesters medicine.medical_treatment Biomedical Engineering Autopsy Tissue plasminogen activator Fibrin medicine Humans General Dentistry Device Removal Aged Aged 80 and over Urokinase Microscopy biology business.industry Stent Thrombosis Middle Aged Blood Vessel Prosthesis Surgery Urokinase receptor biology.protein Female Stents business Tissue ingrowth medicine.drug |
| Zdroj: | Journal of Long-Term Effects of Medical Implants. 23:339-357 |
| ISSN: | 1050-6934 |
| DOI: | 10.1615/jlongtermeffmedimplants.2013006657 |
| Popis: | Using the retrieved devices from one autopsy and five reoperations, the biocompatibility of explanted Talent stent-grafts was investigated to highlight the capacity of the fabric to act as an effective scaffold to regenerate a blood conduit. The autopsy device was encapsulated both internally and externally, but the capsules did not penetrate through the fabric structure. The reoperation devices showed discrete patches of compact fibrin and irregularly scattered mural thrombi. Positive staining of α-actin, tissue plasminogen activator (tPA), urokinase (uPA), urokinase receptor (uPAR), and urokinase inhibitors (PAI 1, PAI 2, PAI 3, and protease nexin), and D-dimer was more frequently identified in the autopsy sample than in the reoperation samples. This preliminary assessment shows that the stent-graft retrieved during autopsy was better healed than those explanted at reoperation. |
| Databáze: | OpenAIRE |
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