Is dose de-escalation possible in sarcoma patients treated with enlarged limb sparing resection?
| Autor: | Antonin Levy, Cécile Le Péchoux, Sylvie Bonvalot, Sara Bellefqih, Axel Le Cesne, Philippe Terrier |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Dose level 030218 nuclear medicine & medical imaging Resection Young Adult 03 medical and health sciences 0302 clinical medicine Humans Medicine Radiology Nuclear Medicine and imaging In patient Aged Retrospective Studies Aged 80 and over business.industry Hazard ratio Soft tissue Dose-Response Relationship Radiation Extremities Radiotherapy Dosage Sarcoma Hematology Middle Aged Limb Salvage medicine.disease Neoadjuvant Therapy Surgery Radiation therapy Oncology 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant Neoplasm Recurrence Local business De-escalation |
| Zdroj: | Radiotherapy and Oncology. 126:493-498 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2017.10.026 |
| Popis: | PURPOSE To evaluate the impact of dose de-escalation in a large series of resected limbs soft tissue sarcomas (STS). METHODS Data were retrospectively analysed from 414 consecutive patients treated for limb STS by enlarged surgery and radiotherapy at Gustave Roussy from 05/1993 to 05/2012. Radiotherapy (RT) dose level was decided by the multidisciplinary staff and depended upon the quality of surgery and margins size. RESULTS RT was delivered prior (13%) or after (87%) surgery. Seven patients (2%) had pre- and a postoperative RT boost. Median delivered RT dose was 50 Gy (36-70 Gy), and 33% received ≥55 Gy. At a median follow-up of 6.8 years, the 5-year actuarial local relapse (LR) rate was 7% (95% CI: 4.4-10%). The median time to the first LR was 2.7 years (range: 0.6-11.2 years). The LR was most often located within the irradiated field (26/32; 81%), where the median total applied dose was 56 Gy (range, 40-60 Gy). The 5-year LR rates were 4%, and 15% in patients receiving |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect