Biosynthesis of Integric Acid Isolated from the Wood-Decay Fungus Xylaria feejeensis 2FB-PPM08M
| Autor: | Hiromitsu Nakajima, Totsaporn Srisapoomi, Tadanori Aimi, Sophon Boonlue, Tsuyoshi Ichiyanagi |
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| Rok vydání: | 2014 |
| Předmět: |
Carboxylic Acids
Mevalonic Acid Fungus Mevalonic acid Acetates Naphthalenes Secondary metabolite Sesquiterpene Applied Microbiology and Biotechnology Microbiology Polyketide chemistry.chemical_compound Methionine Biosynthesis medicine Carbon Isotopes Xylariales biology General Medicine biology.organism_classification Wood-decay fungus chemistry Biochemistry Isotope Labeling Polyketides Mevalonate pathway Sesquiterpenes Metabolic Networks and Pathways medicine.drug |
| Zdroj: | Current Microbiology. 70:550-555 |
| ISSN: | 1432-0991 0343-8651 |
| DOI: | 10.1007/s00284-014-0759-5 |
| Popis: | The biosynthesis of integric acid, a secondary metabolite of the wood-decay fungus Xylaria feejeensis strain 2FB-PPM08M, has been studied. Labeling experiments using [1-(13)C], [2-(13)C] and [1,2-(13)C2] acetate and L-methionine (methyl-(13)C) were separately performed with fungal culture. The labeling patterns of these metabolites indicated the same origin, and determined that integric acid was formed through the condensation of a sesquiterpene and a polyketide. These experiments showed that side chain of compounds would be synthesized by the polyketide pathway, while the ring carbon indicated the biosynthesis of compounds via the mevalonate pathway. |
| Databáze: | OpenAIRE |
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