Rad51 Is an Accessory Factor for Dmc1-Mediated Joint Molecule Formation During Meiosis
| Autor: | Jennifer Grubb, Douglas K. Bishop, Brian Budke, Veronica Cloud, Yuen-Ling Chan |
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| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Saccharomyces cerevisiae Proteins Chromosomal Proteins Non-Histone RAD51 DNA Single-Stranded Cell Cycle Proteins Saccharomyces cerevisiae Biology Genetic recombination Article Recombinases Meiosis Homologous chromosome Interkinesis DNA Fungal Recombination Genetic Multidisciplinary fungi Fungal genetics Molecular biology Cell biology DNA-Binding Proteins enzymes and coenzymes (carbohydrates) Nucleic Acid Conformation Mutant Proteins DMC1 Rad51 Recombinase Homologous recombination Protein Binding |
| Zdroj: | Science. 337:1222-1225 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1219379 |
| Popis: | Relegated to Accessory Critical aspects of meiosis, the specialized cell division that makes haploid gametes and spores, evolved from those of the normal mitotic cell cycle. In mitosis, the RecA homolog Rad51 is required for the homology-mediated repair of DNA double-strand breaks (DSBs). DSBs play a critical role in chromosome segregation in meiosis. Cloud et al. (p. 1222 ) show that the strand-exchange activity of Rad51 is not required in meiosis. Rather, a second meiosis-specific RecA homolog, Dmc1, carries out the homology search and strand-exchange function that Rad51 performs in mitosis, with Rad51 relegated to enhancing the strand-exchange activity of Dmc1. It appears after the gene duplication event that created Dmc1 from an ancestral Rad51. Rad51 took on an accessory role to Dmc1 in meiosis. |
| Databáze: | OpenAIRE |
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