Relationship between antibodies to dsDNA and to soluble cellular antigens and histologically defined glomerulonephritis in patients with SLE
| Autor: | L. Radelli, Riccardo Asero, Bertetti E, Piersandro Riboldi, Giuseppe Banfi, L Origgi, M. Vanoli |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Adolescent Biopsy Immunology Disease Glomerulonephritis Membranous Glomerulonephritis Membranous nephropathy immune system diseases medicine Immunology and Allergy Humans Lupus Erythematosus Systemic In patient Antigens skin and connective tissue diseases biology Proliferative nephritis business.industry Autoantibody Complement C4 Complement C3 DNA Middle Aged medicine.disease Antibodies Antinuclear biology.protein Cellular antigens Female Antibody business |
| Zdroj: | Autoimmunity. 7(1) |
| ISSN: | 0891-6934 |
| Popis: | To better define the relationships between circulating autoantibodies and renal involvement in systemic lupus erythematosus (SLE), antibodies to both dsDNA and soluble cellular antigens were detected in sera from a large series of SLE patients. Significantly higher dsDNA binding activities and lower complement levels at onset were found in patients with renal disease; however, this was uniquely due to subjects with diffuse or focal proliferative glomerulonephritis. Patients with membranous nephropathy (MGN) showed very low dsDNA binding activities (6/9 of them being negative for dsDNA antibodies) and normal mean C3 and C4 levels. A comparison between patients with proliferative nephritis and patients without renal involvement with high dsDNA binding activities revealed significantly lower complement levels in the former group. No significant difference was observed in the prevalence of antibodies to soluble cellular antigens between patients with or without renal disease; however, nRNP antibody was two-fold more frequent in patients with MGN than in all other subgroups. This study highlights the close relationship between concurrently high anti-dsDNA and low complement levels and proliferative glomerulonephritis in SLE, and suggests that subjects with MGN may represent a subgroup of SLE patients showing peculiar serological features. Different mechanisms possibly involved in the pathogenesis of MGN in SLE are discussed. |
| Databáze: | OpenAIRE |
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