Absence of hCG-Like Activity in the Blood of Women Fitted with Intra-Uterine Contraceptive Devices
Autor: | C. S. Corker, H. A. Mclean, R. V Short, Richard M. Sharpe, Bruce Hobson, W Wrixon |
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Rok vydání: | 1977 |
Předmět: |
Adult
Pregnancy test endocrine system medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism media_common.quotation_subject Clinical Biochemistry Radioimmunoassay Uterus Luteal phase Chorionic Gonadotropin Biochemistry Andrology Follicle-stimulating hormone Endocrinology Internal medicine medicine Humans Menstrual cycle media_common business.industry Biochemistry (medical) Luteinizing Hormone Middle Aged Menstruation medicine.anatomical_structure Sephadex Female Follicle Stimulating Hormone Luteinizing hormone business hormones hormone substitutes and hormone antagonists Intrauterine Devices |
Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 45:496-499 |
ISSN: | 1945-7197 0021-972X |
Popis: | Blood was obtained at various stages of the menstrual cycle from 201 women fitted with intra-uterine contraceptive devices (IUDs), and plasma levels of hCG were determined by radioimmunoassay. Urine samples were obtained from 117 of these women and tested, before and after sephadex gel filtration, in a haemagglutination inhibition test for pregnancy (Pregnosticon). Plasma hCG was undetectable (less than 25 MLU/ml) in all but one of the 201 women and, in this instance, the hCG-assay appeared to be measuring a midcycle peak of LH, as evidenced by high plasma FSH levels. All unextracted urines gave negative results in the Pregnosticon test but, after extraction, 18 of the 117 urines gave positive reactions, most of these being from women at midcycle or in the luteal phase. We conclude that the IUD does not permit the development of the embryo to a point where it is capable of secreting measurable amounts of hCG. Recent claims to the contrary are probably due to cross-reaction of LH or non-specific interference in the assays used for measuring hCG. |
Databáze: | OpenAIRE |
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