Pre-emptive administration of corticosteroids prevents the development of ARDS associated with Streptococcus mitis bacteremia following chemotherapy with high-dose cytarabine
| Autor: | J.P. Donnelly, B.E. de Pauw, J.M.M. Raemaekers, E.C. Dompeling |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male ARDS medicine.medical_specialty Adolescent medicine.medical_treatment Bacteremia Adrenal Cortex Hormones Streptococcus mitis Internal medicine Acute lymphocytic leukemia Streptococcal Infections medicine Humans Chemotherapy Respiratory Distress Syndrome biology Respiratory distress Dose-Response Relationship Drug business.industry Cytarabine Hematology General Medicine Middle Aged medicine.disease biology.organism_classification Immunology Female business Complication medicine.drug |
| Zdroj: | Annals of hematology. 69(2) |
| ISSN: | 0939-5555 |
| Popis: | Adult respiratory distress syndrome (ARDS) complicating Streptococcus mitis bacteremia is a major cause of mortality in patients undergoing therapy for leukemia. In order to try to prevent the development of ARDS in 11 patients with S. mitis bacteremia following chemotherapy including cytarabine, high doses of corticosteroids were administered pre-emptively. None of these patients developed ARDS. In a historical control group of 21 comparable patients who had not been given corticosteroids, the incidence of ARDS was high (38%), with a death rate of 14%. Preemptive administration of high-dose corticosteroids appeared to be highly effective in suppressing the mechanisms that induce ARDS in patients with S. mitis bacteremia after cytarabine treatment. The results suggest that ARDS complicating S. mitis bacteremia is not merely a microbiological problem but may, at least in part, represent an immunologically mediated phenomenon. |
| Databáze: | OpenAIRE |
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