Correction of adma-induced preeclampsia with the use of phosphodiesterase 5 and selective inhibitor of arginase II zb49-0010
| Autor: | O.E. Anciferova, O.V. Martynova, M. A. Martynov, T.G. Pokrovskaia, T. I. Lokteva, V.V. Gureev, T.N. Malorodova |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Chemistry General Medicine medicine.disease female genital diseases and pregnancy complications Preeclampsia RATS N-NITRO-L-ARGININE METHYL ESTER ENDOTHELIAL DYSFUNCTION PREECLAMPSIA PHOSPHODIESTERASE 5 A SELECTIVE INHIBITOR OF ARGINASE II Arginase Endocrinology N nitro l arginine methyl ester cGMP-specific phosphodiesterase type 5 Internal medicine embryonic structures medicine Endothelial dysfunction reproductive and urinary physiology |
| Zdroj: | Научный результат. Серия «Медицина и фармация». |
| ISSN: | 2313-8955 |
| Popis: | Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy. In animals, there was an increase in blood pressure, proteinuria, impaired microcirculation in the placenta, the violation of the regulation of vascular tone and destructive changes in the ischemic placenta. The use of phosphodiesterase 5 and selective inhibitor of arginase II ZB49-0010 leads to the expression of morphological and functional correction of violations occurring in modeling of experimental preeclampsia. |
| Databáze: | OpenAIRE |
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