Clinicopathologic significance and prognostic value of Ki-67 expression in patients with gastric cancer: a meta-analysis
| Autor: | You Yang, Zhaowen Luo, Peng Wang, Canchang Cheng, Zhiqiao Zhang, Jinxin Lin, Guanying Luo, Yunzhao Hu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Value (computer science) Review 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Internal medicine Biomarkers Tumor Medicine Humans In patient prognostic value biology business.industry gastric cancer ki-67 Hazard ratio Cancer Odds ratio medicine.disease Prognosis Confidence interval Surgery meta-analysis 030104 developmental biology Ki-67 Antigen 030220 oncology & carcinogenesis Ki-67 Meta-analysis biology.protein Female business |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Guanying Luo 1,2,* , Yunzhao Hu 1,2,* , Zhiqiao Zhang 1,2 , Peng Wang 1 , Zhaowen Luo 2 , Jinxin Lin 2 , Canchang Cheng 1,2 and You Yang 1,2 1 Department of Infectious Diseases, The First People’s Hospital of Shunde, Shunde, Guangdong, China 2 Department of Internal Medicine, The Chencun Affiliated Hospital of First People’s Hospital of Shunde, Shunde, Guangdong, China * These authors have contributed equally to this study and were co-first authors Correspondence to: Zhiqiao Zhang, email: // Keywords : gastric cancer; ki-67;meta-analysis; prognostic value Received : August 01, 2016 Accepted : February 06, 2017 Published : April 20, 2017 Abstract Background: The prognostic value and clinicopathologic significance of Ki-67 expression in gastric cancer patients was controversial. This meta-analysis was performed to clarify the prognostic value and clinicopathologic significance of Ki-67 expression in gastric cancer patients. Materials and Methods: Several electronic databases were searched for eligible studies. The pooled odds ratio (OR), hazard ratios (HR) and 95% confidence interval(CI) were calculated to explore the prognostic value and clinicopathologic significance of Ki-67 expression for disease free survival and overall survival. Results: Totally 5600 gastric cancer patients from 29 studies were included in this study. High Ki-67 expression was significantly related with Lauren’s classification (OR = 1.70; P = 0.001; 95%CI: 1.40-2.06) and tumor size(OR = 1.54; P = 0.006; 95%CI: 1.14-2.09). However, high Ki-67 expression was not significantly associated with lymph node metastasis (OR = 1.37; P = 0.138; 95% CI: 0.90-2.08) , tumor stage (OR = 1.31; P = 0.296; 95% CI: 0.79-2.16) and tumor differentiation (OR = 1.03; P = 0.839; 95% CI: 0.78-1.35). The pooled HRs were 1.87( P = 0.001; 95% CI 1.30-2.69) for disease free survival and 1.23( P = 0.005; 95% CI 1.06-1.42) for overall survival. Conclusions: High Ki-67 expression may serve as a predictive biomarker for poor prognosis in gastric cancer patients. Stratification by Ki-67 expression may be a consideration for selection of therapeutic regimen and integrated managements. |
| Databáze: | OpenAIRE |
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