A tissue-level electromechanical model of the left ventricle: Application to the analysis of intraventricular pressure
Autor: | Philippe Pibarot, Guy Carrault, Alfredo Hernandez, Virginie Le Rolle, Pierre-Yves Richard, Louis-Gilles Durand |
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Přispěvatelé: | Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut d'Électronique et des Technologies du numéRique (IETR), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Institut de cardiologie de Québec, Université Laval [Québec] (ULaval)-Centre Hospitalier de Laval (CH Laval), Biomedical Engineering Laboratory, Université de Montréal (UdeM)-Institut de recherches cliniques de Montréal, The pig experiments were supported by a grant (#6654-01) awarded to Dr. Durand by the National Science and Engineering Research Council of Canada. The authors would like to thank Mr Daniel Lavigne for his contribution in the set-up of the animal experiments and for the recording of the physiological signals., Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Senhadji, Lotfi, Nantes Université (NU)-Université de Rennes 1 (UR1) |
Rok vydání: | 2007 |
Předmět: |
Identification
Computer science Swine 02 engineering and technology 030204 cardiovascular system & hematology Ventricular Function Left Ventricular pressure 0302 clinical medicine [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing General Environmental Science Cardiac cycle [PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] Applied Mathematics Models Cardiovascular Tissue level General Medicine [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system medicine.anatomical_structure Cardiology [SDV.IB]Life Sciences [q-bio]/Bioengineering [INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation General Agricultural and Biological Sciences [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing Algorithms medicine.medical_specialty Materials science [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing Heart Ventricles [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] 0206 medical engineering General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Afterload Biomedical model simulation Internal medicine Biomedical systems modeling medicine Waveform Animals Computer Simulation cardiovascular diseases [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing [SDV.IB] Life Sciences [q-bio]/Bioengineering Model-based interpretation Ellipsoid Myocardial Contraction [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation 020601 biomedical engineering Philosophy Blood pressure Ventricle Intraventricular pressure Bond graph Biomedical engineering |
Zdroj: | Acta Biotheoretica Acta Biotheoretica, Springer Verlag, 2009, 57 (4), pp.457-478. ⟨10.1007/s10441-009-9092-y⟩ Acta Biotheoretica, 2009, 57 (4), pp.457-478. ⟨10.1007/s10441-009-9092-y⟩ |
ISSN: | 0001-5342 1572-8358 |
Popis: | International audience; The ventricular pressure profile is characteristic of the cardiac contraction progress and is useful to evaluate the cardiac performance. In this contribution, a tissue-level electromechanical model of the left ventricle is proposed, to assist the interpretation of left ventricular pressure waveforms. The left ventricle has been modeled as an ellipsoid composed of twelve mechano-hydraulic sub-systems. The asynchronous contraction of these twelve myocardial segments has been represented in order to reproduce a realistic pressure profiles. To take into account the different energy domains involved, the tissue-level scale and to facilitate the building of a modular model, multiple formalisms have been used: Bond Graph formalism for the mechano-hydraulic aspects and cellular automata for the electrical activation. An experimental protocol has been defined to acquire ventricular pressure signals from three pigs, with different afterload conditions. Evolutionary Algorithms have been used to identify the model parameters in order to minimize the error between experimental and simulated ventricular pressure signals. Simulation results show that the model is able to reproduce experimental ventricular pressure. In addition, electro-mechanical activation times have been determined in the identification process. For example, the maximum electrical activation time is reached, respectively, 96.5, 139.3 and 131.5 ms for the first, second, and third pigs. These preliminary results are encouraging for the application of the model on non-invasive data like ECG, arterial pressure or myocardial strain. |
Databáze: | OpenAIRE |
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