Diagnosis of primary immunodeficiencies in Peru
| Autor: | Liz E Veramendi-Espinoza, Juan Carlos Aldave-Becerra, Claudia Alejandra Rentería-Valdiviezo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Government medicine.diagnostic_test Health professionals business.industry Primary Immunodeficiency Diseases MEDLINE Developing country Diagnostic tools Undiagnosed Diseases 03 medical and health sciences 0302 clinical medicine 030225 pediatrics 030220 oncology & carcinogenesis Peru Pediatrics Perinatology and Child Health medicine Humans Intensive care medicine business Genetic testing |
| Zdroj: | Current Opinion in Pediatrics. 32:798-804 |
| ISSN: | 1531-698X 1040-8703 |
| DOI: | 10.1097/mop.0000000000000964 |
| Popis: | Purpose of review Primary immunodeficiencies (PIDs) are human inborn errors of immunity, leading to an increased susceptibility to infections, inflammatory manifestations, and malignancy. We estimate around 16 000 individuals with PIDs living in Peru who are still undiagnosed. The purpose of this review is to make a situational analysis of the diagnosis of PIDs in Peru. Recent findings There is an evident underdiagnosis of PIDs in Peru. Insufficient awareness and lack of diagnostic tools can be solved partially by expanding the number and expertise of Clinical Immunologists and specialized medical centers. The availability of molecular testing at reasonable costs is mandatory to improve the diagnostic approach to patients with suspected PID. The development of didactic and innovative educational tools has been a critical strategy to improve PID awareness and diagnosis in Peru. Summary Developing countries like Peru still have critical limitations to diagnose patients with PIDs such as insufficient awareness in physicians, lack of specialized reference centers, and unavailability of confirmatory genetic testing. Joint work between government, health professionals, patient organizations, and society is essential to overcome these limitations and provide a better future for patients with inborn errors of immunity. |
| Databáze: | OpenAIRE |
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