Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis
Autor: | Ryan Moseley, Adam C. Midgley, Deling Kong, Yifan Tai, Robert Steadman, Jordanna Dally, Emma L. Woods |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Cell wound healing Smad Proteins macromolecular substances Review Ligands Biochemistry Microbiology Transforming Growth Factor beta1 03 medical and health sciences Cicatrix Mice 0302 clinical medicine Fibrosis medicine Animals Humans Hyaluronic Acid Myofibroblasts Molecular Biology transforming growth factor-β1 Cells Cultured beta Catenin anti-scarring therapy Skin Cell phenotype business.industry fibrosis Cell Differentiation medicine.disease Phenotype QR1-502 myofibroblast Actins Review article ErbB Receptors Wnt Proteins 030104 developmental biology medicine.anatomical_structure Hyaluronan Receptors 030220 oncology & carcinogenesis business Wound healing Myofibroblast Neuroscience Function (biology) Signal Transduction |
Zdroj: | Biomolecules Biomolecules, Vol 11, Iss 1095, p 1095 (2021) |
ISSN: | 2218-273X |
Popis: | Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in pathophysiological processes. Myofibroblasts mediate wound contractions, but their persistent presence in tissues is central to driving fibrosis, making them attractive cell targets for the development of therapeutic treatments. However, due to shared cellular markers with several other phenotypes, the specific targeting of myofibroblasts has long presented a scientific and clinical challenge. In recent years, myofibroblasts have drawn much attention among scientific research communities from multiple disciplines and specialisations. As further research uncovers the characterisations of myofibroblast formation, function, and regulation, the realisation of novel interventional routes for myofibroblasts within pathologies has emerged. The research community is approaching the means to finally target these cells, to prevent fibrosis, accelerate scarless wound healing, and attenuate associated disease-processes in clinical settings. This comprehensive review article describes the myofibroblast cell phenotype, their origins, and their diverse physiological and pathological functionality. Special attention has been given to mechanisms and molecular pathways governing myofibroblast differentiation, and updates in molecular interventions. |
Databáze: | OpenAIRE |
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