Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients
| Autor: | Zhigang Song, Jingmin Gu, Jianzhong Zhang, Ruoming Tan, Jia Dai, Feng Li, Jing Jin, Yuan Gao, Xiaokui Guo, Jinfeng Cai, Demeng Tan, Qingguo Wu, Zhaoqin Zhu, Li-Kuang Chen, Yiyuan Zhang, Hongzhou Lu, Hongping Qu, Mengjun Cheng, Yun Ling, Bangxin Yao, Jie Li, Lei Shi, Shunpeng Xing, Nannan Wu, Tongyu Zhu, Mingquan Guo, Linlin Li, Shuai Le, Jinhong Qin, Jianhui Li, Lan Yang, Xin Zhou, Tao Li, Ming-Li Zhu |
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| Rok vydání: | 2021 |
| Předmět: |
Acinetobacter baumannii
Male 0301 basic medicine Phage therapy Epidemiology viruses medicine.medical_treatment Antibiotics law.invention law Drug Discovery Medicine Bacteriophages Aged 80 and over medicine.diagnostic_test biology Coinfection food and beverages General Medicine Podoviridae Intensive care unit Infectious Diseases Female medicine.symptom Research Article Acinetobacter Infections animal structures medicine.drug_class 030106 microbiology Immunology Microbiology 03 medical and health sciences Virology nosocomial infections Humans Aged SARS-CoV-2 business.industry COVID-19 Outbreak carbapenem-resistant Acinetobacter baumannii medicine.disease biology.organism_classification body regions 030104 developmental biology Bronchoalveolar lavage Sputum Parasitology business |
| Zdroj: | Emerging Microbes & Infections article-version (VoR) Version of Record |
| ISSN: | 2222-1751 |
| DOI: | 10.1080/22221751.2021.1902754 |
| Popis: | Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVID-19 and pulmonary carbapenem-resistant Acinetobacter baumannii (CRAB) infections to compassionate phage therapy (at 2 successive doses of 109 plaque-forming unit phages). All patients in our COVID-19-specific intensive care unit (ICU) with CRAB positive in bronchoalveolar lavage fluid or sputum samples were eligible for study inclusion if antibiotic treatment failed to eradicate their CRAB infections. While phage susceptibility testing revealed an identical profile of CRAB strains from these patients, treatment with a pre-optimized 2-phage cocktail was associated with reduced CRAB burdens. Our results suggest the potential of phages on rapid responses to secondary CRAB outbreak in COVID-19 patients. |
| Databáze: | OpenAIRE |
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