The genetic influence of the brain-derived neurotrophic factor Val66Met polymorphism in chronic low back pain
| Autor: | Daniel Simon, Angela Shiratsu Yamada, Flavia Tasmim Techera Antunes, Camila Ferraz, Alessandra Hubner de Souza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Biopsychosocial model
Catastrophization Single-nucleotide polymorphism Diseases of the musculoskeletal system Hospital Anxiety and Depression Scale 03 medical and health sciences 0302 clinical medicine Rheumatology Polymorphism (computer science) Val66Met Medicine Humans Polymorphism 030203 arthritis & rheumatology Brain-derived neurotrophic factor Catastrophizing Polymorphism Genetic business.industry Brain-Derived Neurotrophic Factor Central sensitization RC581-607 humanities Single nucleotide polymorphism BDNF RC925-935 Roland Morris Disability Questionnaire Pain catastrophizing Chronic Pain Immunologic diseases. Allergy business Low Back Pain 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Advances in Rheumatology, Vol 61, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2523-3106 |
| Popis: | Background The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is a potential biomarker of vulnerability to pain. Thus, the present study aimed to investigate the association of this polymorphism with clinical and biopsychosocial factors in patients with chronic low back pain (CLBP). Methods A total of 107 individuals with CLBP answered questionnaires that were validated and adapted for the Brazilian population, including the Brief Inventory of Pain, the Central Sensitization Inventory, the Roland Morris Disability Questionnaire, the Tampa Scale for Kinesiophobia, the Pain Catastrophizing Scale, the Survey of Pain Attitude-Brief, and the Hospital Anxiety and Depression Scale. All of the subjects were genotyped for the BDNF Val66Met polymorphism. Results The sample showed moderate scores of disability, central sensitization, and kinesiophobia, in addition to mild anxiety, hopelessness, and ruminant thoughts. No significant association was observed between the Val66Met polymorphism and the variables analyzed. Besides, there was no relationship between the BDNF Val66Met polymorphism with CSI, catastrophization, or disabilities that were generated by CLBP. Conclusion The results showed that the Val66Met polymorphism of the BDNF gene was not associated with clinical and biopsychosocial characteristics of CLBP in the sample studied. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink