Hypocholesterolaemic and Anti-Atherogenic Effects of Palm-Based Oils (NoveLin I and NoveLin II) in Cholesterol-Fed Rabbits
| Autor: | Che Anishas Che Idris, Ahmad Faizal Abdull Razis, Siew Wai Lin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
food.ingredient 030309 nutrition & dietetics Health Toxicology and Mutagenesis High density lcsh:Medicine 030209 endocrinology & metabolism Article palm-based 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food Fibrous plaque Animals Plant Oils Food science NoveLin II Hypolipidemic Agents chemistry.chemical_classification 0303 health sciences Chemistry Cholesterol Moderate level Coconut oil lcsh:R Public Health Environmental and Occupational Health cholesterol NoveLin I Atherosclerosis Dietary Fats Lower total cholesterol Anti atherogenic Coconut Oil lipids (amino acids peptides and proteins) Rabbits Polyunsaturated fatty acid |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 9 International Journal of Environmental Research and Public Health, Vol 17, Iss 3226, p 3226 (2020) |
| ISSN: | 1660-4601 |
| Popis: | NoveLin I and NoveLin II are palm-based oils. NoveLin I has an equal distribution of saturated, monounsaturated and polyunsaturated fatty acids, whereas NoveLin II has a moderate level of monounsaturated fatty acids, and a lower content of saturated and polyunsaturated fatty acids. However, their hypocholesterolaemic and anti-atherogenic effects have not been studied. Therefore, this study aimed to assess the hypocholesterolaemic and anti-atherogenic effects of these oils. Forty male New Zealand White rabbits were divided into four groups and fed with diets containing 35% energy fat with added 0.15% (w/w) dietary cholesterol. Group 1, as the control group (CNO) was fed with a diet containing coconut oil, group 2 and 3 were fed with diets containing either NoveLin I or NoveLin II, and group 4, was fed with diet containing olive oil (OLV) for 100 days. Our results demonstrated that both NoveLin groups have significantly lower total cholesterol and low-density lipoprotein&ndash cholesterol (LDL&ndash C) compared to CNO group and are comparable to the OLV group. Low density lipoprotein&ndash cholesterol/high density lipoprotein-cholesterol (LDL/HDL&ndash C) ratio was significantly lower after the NoveLin II diet but attained significance only in comparison to NoveLin I and CNO groups. Aortic fibrous plaque score was significantly lower in both NoveLin groups compared to CNO group. Our findings suggest that despite the high-fat cholesterol diet, NoveLin II oil resulted in atherogenic effects comparable to olive oil. |
| Databáze: | OpenAIRE |
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