Clinical trials on pain lowering effect of ginger: A narrative review
| Autor: | Vittoria Infantino, Giancarlo Iannello, Gabriella Peroni, Viviana Vecchio, Antonella Riva, Simone Perna, Federica Fossari, Clara Gasparri, Mara Nichetti, Mariangela Rondanelli, Giovanna Petrangolini, Daniele Spadaccini |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
myalgia
Male medicine.medical_specialty ginger Pain Reviews Osteoarthritis Review dysmenorrhea knee osteoarthritis law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Delayed onset muscle soreness medicine Humans Pain Measurement Randomized Controlled Trials as Topic Pharmacology 0303 health sciences business.industry 030302 biochemistry & molecular biology medicine.disease Clinical trial Migraine 030220 oncology & carcinogenesis Nociceptor chronic low back pain Narrative review Female medicine.symptom business |
| Zdroj: | Phytotherapy Research |
| ISSN: | 1099-1573 |
| Popis: | Ginger has a pain-reducing effect and it can modulate pain through various mechanisms: inhibition of prostaglandins via the COX and LOX-pathways, antioxidant activity, inibition of the transcription factor nf-kB, or acting as agonist of vanilloid nociceptor. This narrative review summarizes the last 10-year of randomized controlled trials (RCTs), in which ginger was traditionally used as a pain reliever for dysmenorrhea, delayed onset muscle soreness (DOMS), osteoarthritis (AO), chronic low back pain (CLBP), and migraine. Regarding dysmenorrhea, six eligible studies suggest a promising effect of oral ginger. As concerned with DOMS, the four eligible RCTs suggested a reduction of inflammation after oral and topical ginger administration. Regarding knee AO, nine RCTs agree in stating that oral and topical use of ginger seems to be effective against pain, while other did not find significant differences. One RCT considered the use of ginger in migraine and suggested its beneficial activity. Finally, one RCT evaluated the effects of Swedish massage with aromatic ginger oil on CLBP demonstrated a reduction in pain. The use of ginger for its pain lowering effect is safe and promising, even though more studies are needed to create a consensus about the dosage of ginger useful for long-term therapy. |
| Databáze: | OpenAIRE |
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