Early glottic cancer in a veteran population: Impact of race on management and outcomes
| Autor: | Tanner Fullmer, Donald T. Donovan, David J. Hernandez, Justin Shi, Robert B. Parke, Andrew T. Huang, Heath D. Skinner, Vlad C. Sandulache, Weiyuan Mai |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Oncology Glottis medicine.medical_specialty Population impact Population Risk Assessment Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Risk factor 030223 otorhinolaryngology education Lung cancer Laryngeal Neoplasms Aged Neoplasm Staging Retrospective Studies Veterans education.field_of_study business.industry Head and neck cancer Disease Management Evidence-based medicine Middle Aged Prognosis medicine.disease Combined Modality Therapy United States Glottic Squamous Cell Carcinoma Survival Rate Otorhinolaryngology Glottic cancer 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Morbidity business |
| Zdroj: | The Laryngoscope. 130:1733-1739 |
| ISSN: | 1531-4995 0023-852X |
| Popis: | Objectives Multiple population studies have shown racial discrepancies in head and neck cancer treatment and outcomes. We sought to characterize the impact of race on clinical outcomes for patients with early glottic squamous cell carcinoma (SCC) in a tertiary institution which provides equivalent access to care. Methods We retrospectively reviewed all early glottic (T1-T2) squamous cell carcinoma at a single institution, the Michael E. DeBakey Veterans' Administration Medical Center (MEDVAMC). Data collected included demographic information, primary and adjuvant treatment modalities, time to diagnosis, time to treatment, recurrences, recurrence treatment modality, secondary malignancies, recurrence-free survival (RFS), and overall survival (OS). Results One hundred seventeen patients with a primary diagnosis of T1-T2 glottic squamous cell carcinoma were included. Black and white patients demonstrated equivalent rates of recurrence, RFS, and OS. There was no significant difference in treatment delivery by race for all recorded parameters. T1b tumors were associated with an increased risk of recurrence which did not translate into a statistically significant decrease in RFS or OS. Surgical treatment was associated with increased recurrence but similar RFS and OS compared to radiation-based treatment. Secondary malignancies were common; 12% of patients were diagnosed with a second primary lung cancer during the study period. Conclusion At our institution, race did not impact survival when access to care, treatment selection, and delivery are equivalent for early glottic SCC. Secondary lung cancer is a critical risk factor for mortality in this patient group and requires long-term surveillance and monitoring. Level of evidence 4 Laryngoscope, 130:1733-1739, 2020. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text