Imiquimod 5% cream for external genital or perianal warts in human immunodeficiency virus-positive patients treated with highly active antiretroviral therapy: an open-label, noncomparative study

Autor: Philippe Saiag, Christiane Mougin, F. Bouscarat, A. Bauhofer, C. Aquilina, J. P. Ortonne, Nicolas Dupin
Přispěvatelé: Science et Ingénierie des Matériaux et Procédés (SIMaP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Science et Ingénierie des Matériaux et Procédés ( SIMaP ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC )
Rok vydání: 2009
Předmět:
Sexually transmitted disease
Male
MESH: Adjuvants
Immunologic
Imiquimod
Kaplan-Meier Estimate
MESH : Anus Diseases
MESH: Papillomavirus Infections
MESH : Aminoquinolines
MESH: Anus Diseases
MESH: Antiretroviral Therapy
Highly Active
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
Genital warts
chemistry.chemical_compound
0302 clinical medicine
Immunopathology
Antiretroviral Therapy
Highly Active
MESH: Aminoquinolines
MESH : Female
MESH: Kaplan-Meiers Estimate
030212 general & internal medicine
Trichloroacetic acid
MESH: Treatment Outcome
MESH : Papillomavirus Infections
MESH : AIDS-Related Opportunistic Infections
MESH: Middle Aged
MESH: AIDS-Related Opportunistic Infections
virus diseases
MESH : Adult
Condyloma Acuminatum
Middle Aged
MESH: Administration
Cutaneous
3. Good health
MESH : Condylomata Acuminata
Podophyllotoxin
Treatment Outcome
MESH: Young Adult
Condylomata Acuminata
030220 oncology & carcinogenesis
Aminoquinolines
Female
medicine.drug
Adult
medicine.medical_specialty
Adolescent
MESH : Male
MESH : Drug Administration Schedule
MESH : Young Adult
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH : Treatment Outcome
Dermatology
MESH: Drug Administration Schedule
Administration
Cutaneous
Drug Administration Schedule
03 medical and health sciences
Young Adult
Acquired immunodeficiency syndrome (AIDS)
Adjuvants
Immunologic
MESH : Adolescent
medicine
Humans
MESH : Middle Aged
MESH : Administration
Cutaneous
MESH: Adolescent
Anus Diseases
MESH: Humans
AIDS-Related Opportunistic Infections
business.industry
MESH : Humans
Papillomavirus Infections
MESH : Kaplan-Meiers Estimate
MESH: Adult
MESH : Antiretroviral Therapy
Highly Active
medicine.disease
MESH: Male
chemistry
Immunology
MESH : Adjuvants
Immunologic
MESH: Condylomata Acuminata
business
MESH: Female
Zdroj: British Journal of Dermatology
British Journal of Dermatology, Wiley, 2009, 161 (4), pp.904-9. ⟨10.1111/j.1365-2133.2009.09210.x⟩
British Journal of Dermatology, Wiley, 2009, 161 (4), pp.904-9. 〈10.1111/j.1365-2133.2009.09210.x〉
ISSN: 1365-2133
0007-0963
DOI: 10.1111/j.1365-2133.2009.09210.x⟩
Popis: Summary Background Human immunodeficiency virus (HIV)+ patients have an increased risk of anogenital warts. High-risk (HR) human papillomaviruses (HPVs), especially types 16 and 18, are major risk factors for precancerous and cancerous lesions of the anogenital tract, while low-risk (LR) HPVs are associated with benign lesions. Cure of genital warts with ablative techniques, surgical excision, podophyllotoxin or trichloroacetic acid is frequently difficult. Treatment with imiquimod cream showed a total clearance of external genital or perianal warts in about 50% of immunocompetent subjects. However, total clearance was reduced in HIV+ subjects not treated with highly active antiretroviral therapy (HAART). Objectives To assess clinically and by monitoring HPV content the efficacy of 5% topical imiquimod to treat anogenital warts in HIV+ subjects with at least partially restored immune functions. Methods Fifty HIV+ patients successfully treated with HAART (total CD4+ cells ≥ 200 cells mm−3 and plasma HIV RNA load
Databáze: OpenAIRE
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