Hair Mineral and Trace Element Content in Children with Down's Syndrome
Autor: | A.R. Grabeklis, Alexey A. Tinkov, Anastasia A. Skalnaya, Irina V. Zhegalova, Anna L. Mazaletskaya, Anatoly V. Skalny, Margarita G. Skalnaya, Svetlana V. Notova |
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Rok vydání: | 2018 |
Předmět: |
Male
Down syndrome Endocrinology Diabetes and Metabolism Clinical Biochemistry Significant group chemistry.chemical_element 010501 environmental sciences 01 natural sciences Biochemistry Inorganic Chemistry 03 medical and health sciences Animal science medicine Humans Inductively coupled plasma mass spectrometry 0105 earth and related environmental sciences 0303 health sciences Minerals S syndrome 030302 biochemistry & molecular biology Biochemistry (medical) Trace element Infant General Medicine medicine.disease Mercury (element) Trace Elements Hair mercury chemistry Case-Control Studies Child Preschool Female Trace element analysis Down Syndrome Hair |
Zdroj: | Biological trace element research. 188(1) |
ISSN: | 1559-0720 |
Popis: | The objective of the present study was to assess the level of minerals and trace elements in 40 children with Down's syndrome and 40 controls aged 1-2 years old. Hair mineral and trace element analysis was performed using inductively coupled plasma mass spectrometry. The obtained data demonstrate that hair levels of Mg, P, I, Cr, Si, Zn, and Pb in Down's syndrome patients exceeded the respective control values by 36, 36, 93, 57, 45, 28, and 54%, whereas hair mercury was more than twofold lower in children with Down's syndrome. The observed difference in the levels of trace elements was age-dependent. In particular, in 1-year-olds, major differences were observed for essential elements (Cr, Si, Zn), whereas in 2-year-olds-for toxic elements (Hg, Pb). At the same time, hair P levels in Down's syndrome patients were 14 and 35% higher at the age of 1 and 2 years in comparison to the respective controls. Multiple regression analysis demonstrated that a model incorporating all elements, being characterized by a significant group difference, accounted for 42.5% of status variability. At the same time, only hair phosphorus was significantly interrelated with Down's syndrome status (β = 0.478; p |
Databáze: | OpenAIRE |
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