Cortical functional activity in patients with generalized anxiety disorder
| Autor: | Lingjiang Li, Fangxian Chai, Lixia Yang, Pingxia Xie, Deyu Fang, Lei Zheng, Xingde Liu, Yiming Wang, Hongming Zhang |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Generalized anxiety disorder Prefrontal Cortex Electroencephalography 03 medical and health sciences Young Adult 0302 clinical medicine Rating scale Internal medicine medicine Humans Young adult Psychiatry Prefrontal cortex Depression (differential diagnoses) Aged Cerebral Cortex medicine.diagnostic_test Cortical functional activity Middle Aged medicine.disease Correlation dimension Anxiety Disorders 030227 psychiatry Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health medicine.anatomical_structure Cerebral cortex Case-Control Studies Anxiety Female medicine.symptom Psychology 030217 neurology & neurosurgery Research Article EEG nonlinear analysis |
| Zdroj: | BMC Psychiatry |
| ISSN: | 1471-244X |
| Popis: | Background The neurological correlates of Generalised Anxiety Disorder (GAD) are not well known, however there is evidence of cortical dysregulation in patients with GAD. The aim of the study was to examine cortical functional activity in different cerebral regions in patients with GAD using electroencephalogram (EEG) nonlinear analysis to evaluate its contribution of anxiety severity. Methods The cohorts consisted of 64 patients diagnosed with GAD as classified by the Structured Clinical Interview for the Diagnostic and Statistical Manual of the American Psychiatric Association-IV-TR. Anxiety severity was assessed using the Hamilton Rating Scale for Anxiety (HAMA) severity score, with 7 ≤ scores ≤ 17 indicating mild anxiety as A group (n = 31) and 18 and above indicating moderate-severe anxiety as B group (n = 33). Participants with clinical levels of depression symptoms were excluded. A healthy control group comprising 30 participants was matched for age and gender. Closed eyes EEGs were conducted, and between-group differences on non-linear parameter Correlation Dimension (D2) were analyzed. The association of D2 value with HAMA scores was analyzed using multiple linear stepwise regression. Results Compared with the control group, D2 values were increased in anxiety groups (P |
| Databáze: | OpenAIRE |
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