Growth hormones therapy in immune response against Trypanosoma cruzi
| Autor: | Eduardo Osório Frare, Leony Cristina Caetano, Míriam Paula Alonso Toldo, Jerri C. Caldeira, José Clóvis do Prado, Fabricia Helena Santello |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Chagas disease medicine.medical_specialty Trypanosoma cruzi Parasitemia Nitric Oxide Nitric oxide chemistry.chemical_compound Immune system Immunity Internal medicine medicine Animals Chagas Disease Rats Wistar Amastigote General Veterinary biology Tumor Necrosis Factor-alpha Heart biology.organism_classification medicine.disease Rats Endocrinology chemistry Growth Hormone Hormone |
| Zdroj: | Research in Veterinary Science. 88:273-278 |
| ISSN: | 0034-5288 |
| DOI: | 10.1016/j.rvsc.2009.10.001 |
| Popis: | Growth hormone (GH) is an important hypophyseal hormone that is primarily involved in body growth and metabolism. In mammals, control of Trypanosoma cruzi parasitism during the acute phase of infection is considered to be critically dependent on direct macrophage activation by cytokines. To explore the possibility that GH might be effective in the treatment of Chagas' disease, we investigated its effects on the course of T. cruzi infection in rats, focusing our analyses on its influences on parasitemia, NO, TNF-alpha and IFN-gamma concentration and on histopathological alterations and parasite burden in heart tissue. T. cruzi-infected male Wistar rats were intraperitoneally treated with 5 ng/10 g body weight/day of GH. Animals treated with GH showed a significant reduction in the number of blood trypomastigotes during the acute phase of infection compared with untreated animals (P |
| Databáze: | OpenAIRE |
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