Change in prepregnancy body mass index and gastroschisis
| Autor: | Mark A. Canfield, Renata H. Benjamin, Laura E. Mitchell, Mary K. Ethen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Epidemiology Weight Gain Logistic regression 01 natural sciences Body Mass Index Odds Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Weight Loss medicine Humans Mass index Obesity 030212 general & internal medicine 0101 mathematics Gastroschisis Obstetrics business.industry 010102 general mathematics Odds ratio medicine.disease Texas United States Confidence interval Pregnancy Complications Case-Control Studies Female business Body mass index |
| Zdroj: | Annals of Epidemiology. 41:21-27 |
| ISSN: | 1047-2797 |
| Popis: | Purpose Maternal body mass index (BMI) is inversely associated with gastroschisis, but a causal relationship has not been established. As data demonstrating that a change in exposure status is related to a change in the frequency of the outcome can add to the evidence for causality, we conducted a case-control study of change in maternal BMI, assessed using interpregnancy change in BMI (IPC-BMI), and gastroschisis. Methods Data for 258 gastroschisis cases and 2,561 controls were obtained from the Texas Birth Defects Registry and vital records (2006-2012). Logistic regression was used to estimate the adjusted association between IPC-BMI and gastroschisis. Results The continuous IPC-BMI variable was inversely associated with gastroschisis (adjusted odds ratio [aOR]=0.90, 95% confidence interval [CI]: 0.86-0.95). When assessed as a six-level categorical variable, with weight stable women as the referent, the odds of gastroschisis were higher following a BMI decrease of >1 unit (aOR=1.37, 95% CI: 0.91-2.06) and lower after a BMI increase of > 3 units (aOR=0.62, 95% CI: 0.42-0.94) Conclusions Our findings suggest that maternal change in BMI is associated with gastroschisis and, thus, add to the epidemiological evidence that can be used to inform our understanding of the relationship between BMI and gastroschisis. |
| Databáze: | OpenAIRE |
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