Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus
| Autor: | Hong Kyu Lee, Young Min Cho, Moon Yeon Youn, Kang-Yeol Yu, Kyong Soo Park, Seong Yeon Kim, Young Joo Park, Hong Je Park, Byung-Soo Youn, Sung Shik Min, Nam Seok Lee |
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| Rok vydání: | 2004 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Blood Pressure Enzyme-Linked Immunosorbent Assay Type 2 diabetes Biochemistry Body Mass Index Endocrinology Insulin resistance Internal medicine Blood plasma medicine Homeostasis Humans Resistin Aged Adiponectin business.industry Biochemistry (medical) nutritional and metabolic diseases Type 2 Diabetes Mellitus Antibodies Monoclonal respiratory system Middle Aged medicine.disease Obesity Cholesterol Diabetes Mellitus Type 2 Hormones Ectopic Body Constitution Female Insulin Resistance business hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 89(1) |
| ISSN: | 0021-972X |
| Popis: | Resistin is an adipocyte-derived peptide that might play a role in obesity and insulin resistance. However, its role in humans is largely unclear. Although many studies have measured the expression of human resistin in tissues, the circulating concentrations of resistin and its relation to metabolic parameters in humans are unknown. We developed an ELISA for human resistin and measured plasma concentrations in aged individuals with or without type 2 diabetes mellitus. To validate the results of plasma resistin concentrations in our subjects, plasma adiponectin concentrations were also determined, which were higher in nondiabetic subjects than in type 2 diabetic patients and correlated with the homeostasis model assessment for insulin resistance (HOMA-IR). Log-transformed plasma resistin concentrations (log-resistin) were higher in diabetic patients compared with normal individuals (0.50 +/- 0.39 vs. 0.28 +/- 0.51 ng/ml; P0.001), and this difference was significant after controlling for gender and body mass index. Log-resistin did not show a significant correlation with HOMA-IR, waist circumference, body mass index, blood pressure, or total cholesterol. The plasma glucose concentration was an independent factor associated with log-resistin. In conclusion, plasma resistin concentrations are elevated in patients with type 2 diabetes, but are not associated with insulin resistance or obesity. |
| Databáze: | OpenAIRE |
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