Notch3 signalling and vascular remodelling in pulmonary arterial hypertension
| Autor: | Hannah Morris, Karla B Neves, Rhian M. Touyz, Augusto C. Montezano, Margaret R. MacLean |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Gene isoform RM Vascular smooth muscle Myocytes Smooth Muscle Notch signaling pathway Pulmonary Artery Vascular Remodeling Molecular Bases of Health & Disease Muscle Smooth Vascular Vascular remodelling in the embryo 03 medical and health sciences 0302 clinical medicine medicine.artery medicine vascular smooth muscle cells Animals Humans Review Articles Receptor Notch3 Pulmonary Arterial Hypertension business.industry Hes Cell Differentiation General Medicine Phenotype Signaling Pathophysiology Cell biology 030104 developmental biology Cardiovascular System & Vascular Biology pulmonary arteries 030220 oncology & carcinogenesis Notch receptors Pulmonary artery Hey cardiovascular system Translational Science Signal transduction business signal transduction |
| Zdroj: | Clinical Science (London, England : 1979) |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs20190835 |
| Popis: | Notch signalling is critically involved in vascular morphogenesis and function. Four Notch isoforms (Notch1–4) regulating diverse cellular processes have been identified. Of these, Notch3 is expressed almost exclusively in vascular smooth muscle cells (VSMCs), where it is critically involved in vascular development and differentiation. Under pathological conditions, Notch3 regulates VSMC switching between the contractile and synthetic phenotypes. Abnormal Notch3 signalling plays an important role in vascular remodelling, a hallmark of several cardiovascular diseases, including pulmonary arterial hypertension (PAH). Because of the importance of Notch3 in VSMC (de)differentiation, Notch3 has been implicated in the pathophysiology of pulmonary vascular remodelling in PAH. Here we review the current literature on the role of Notch in VSMC function with a focus on Notch3 signalling in pulmonary artery VSMCs, and discuss potential implications in pulmonary artery remodelling in PAH. |
| Databáze: | OpenAIRE |
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