Invasive pneumococcal disease : Clinical outcomes and patient characteristics 2-6 years after introduction of 7-valent pneumococcal conjugate vaccine compared to the pre-vaccine period, the Netherlands

Autor: Arie van der Ende, Karin E. M. Elberse, Hester E. de Melker, Elisabeth A. M. Sanders, Bart J. M. Vlaminckx, Mirjam J. Knol, Gertjan H.J. Wagenvoort
Přispěvatelé: AII - Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Serotype
Pediatrics
Heptavalent Pneumococcal Conjugate Vaccine
Epidemiology
medicine.disease_cause
Pneumococcal conjugate vaccine
0302 clinical medicine
Clinical outcomes
030212 general & internal medicine
Child
Non-U.S. Gov't
Netherlands
Aged
80 and over
Incidence (epidemiology)
Incidence
Research Support
Non-U.S. Gov't
Invasive pneumococcal disease
Middle Aged
Pneumococcal infections
Streptococcus pneumoniae
Infectious Diseases
Child
Preschool
Molecular Medicine
Public Health
Meningitis
medicine.drug
Adult
medicine.medical_specialty
Adolescent
030106 microbiology
Sentinel surveillance
Serogroup
Research Support
Pneumococcal Infections
03 medical and health sciences
Young Adult
Immunology and Microbiology(all)
medicine
Journal Article
Humans
Empyema
Aged
General Veterinary
General Immunology and Microbiology
business.industry
Environmental and Occupational Health
Infant
Newborn
Public Health
Environmental and Occupational Health
Infant
medicine.disease
veterinary(all)
Pneumonia
business
Zdroj: Vaccine, 34(8), 1077. Elsevier BV
Vaccine, 34(8), 1077-1085. Elsevier BV
ISSN: 0264-410X
Popis: Background Implementation of 7-valent pneumococcal conjugate vaccine (PCV7) in the Dutch national immunization program for infants led to a shift from vaccine to non-vaccine serotypes in invasive pneumococcal disease (IPD) in all age groups. We studied the impact of the serotype shift on clinical syndromes and outcomes. Methods Pneumococcal isolates from hospitalized IPD patients obtained from nine sentinel microbiology laboratories, covering 25% of the Dutch population, were serotyped. Clinical syndromes, outcomes and patient characteristics in the post-PCV7 (2008–2012) period were compared with the pre-PCV7 period (2004–2006). Serotype specific propensity of the association with empyema, meningitis and death was calculated. Results Invasive pneumonia incidence significantly decreased in children
Databáze: OpenAIRE
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