Investigation of the metabolic difference between ST-elevated myocardial infarction and non-ST-elevated myocardial infarction via LC/Q-TOF/MS/MS

Autor:	Gulsah Gundogdu, Fatma Demirkaya Miloglu, Yavuzer Koza, Onur Senol, Fuat Gundogdu
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Acute coronary syndrome medicine.medical_specialty Metabolite lcsh:Analytical chemistry General Physics and Astronomy 030204 cardiovascular system & hematology medicine.disease_cause General Biochemistry Genetics and Molecular Biology STEMI lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine LC/Q-TOF/MS/MS Internal medicine medicine Metabolomics General Materials Science Human Metabolome Database Myocardial infarction Carnitine METLIN 030304 developmental biology General Environmental Science 0303 health sciences lcsh:QD71-142 business.industry General Chemistry medicine.disease NSTEMI chemistry lcsh:QD1-999 Cardiology Biomarker (medicine) business Oxidative stress medicine.drug
Zdroj:	Journal of Analytical Science and Technology, Vol 10, Iss 1, Pp 1-9 (2019)
ISSN:	2093-3371
Popis:	Acute coronary syndrome (ACS) is a clinical condition caused by a disturbance in myocardial blood flow. ACS can be basically divided into two forms: ST elevation myocardial infarction (STEMI) due to complete occlusion of the coronary artery and non-ST elevation myocardial infarction (NSTEMI) due to partial occlusion of the coronary artery. In this study, we aimed to monitor the metabolite profile of STEMI and NSTEMI patients and compare the results via untargeted metabolomics approach. Serum samples were collected from STEMI and NSTEMI patients, and each group consists of 20 participants. Extraction was achieved by acetonitrile, and chromatographic separation was performed by LC/Q-TOF/MS/MS accompanied with dual AJS ESI positive ion mode. METLIN, MATLAB 2017a-PLS Toolbox7.2, and Human Metabolome Database were utilized for bioinformatics evaluation of obtained findings. In our results, 203 m/z ratio was detected and 163 m/z ratio passed the significance criteria (fold analysis > 1.5 and p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec67616a422967779f9f9e474c2a147a http://link.springer.com/article/10.1186/s40543-019-0191-3 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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