Mycobacterium ulcerans infection (Buruli ulcer) in French Guiana, South America, 1969–2013: an epidemiological study
| Autor: | Sylvain Labbé, Dominique Sainte-Marie, Roger Pradinaud, Rodolphe E. Gozlan, Mathieu Nacher, Jean-François Guégan, Maylis Douine, J. Dufour, Pierre Couppié, Yann Reynaud, Christine Chevillon, Alain Berlioz-Arthaud, Marine Combe, Eric Elguero, Camilla Jensen Velvin |
|---|---|
| Přispěvatelé: | Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine [Cayenne] (COREVIH), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Evolution of host-microbe communities (MIVEGEC-EVCO), Processus Écologiques et Évolutifs au sein des Communautés (PEEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut Pasteur de la Guyane, Service de Dermatologie [Cayenne, Guyanne Française], Centre Hospitalier Andre Rosemon, This work was funded by an 'Investissement d’Avenir' grant managed by Agence Nationale de la Recherche (Centre d’Étude de la Biodiversité Amazonienne, reference ANR-10-LABX-2501)., Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Génétique et évolution des maladies infectieuses (GEMI), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Génétique et évolution des maladies infectieuses (GEMI) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Buruli ulcer Health (social science) Medicine (miscellaneous) MESH: Mycobacterium ulcerans MESH: Buruli Ulcer/epidemiology 0302 clinical medicine MESH: Aged 80 and over [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Child Epidemiology 030212 general & internal medicine MESH: Incidence Child Buruli Ulcer lcsh:Environmental sciences lcsh:GE1-350 Aged 80 and over MESH: Aged MESH: Middle Aged biology Transmission (medicine) Incidence Health Policy Incidence (epidemiology) MESH: Infant Newborn Middle Aged MESH: Infant French Guiana 3. Good health MESH: Young Adult Child Preschool Mycobacterium ulcerans [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases Female Leprosy Adult medicine.medical_specialty Tuberculosis Adolescent MESH: French Guiana/epidemiology 030231 tropical medicine Bone Infection Young Adult 03 medical and health sciences medicine Humans Aged MESH: Adolescent MESH: Humans business.industry MESH: Child Preschool Infant Newborn Public Health Environmental and Occupational Health Infant MESH: Adult medicine.disease biology.organism_classification Dermatology MESH: Male Surgery [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business MESH: Female |
| Zdroj: | Lancet Planetary Health Lancet Planetary Health, Elsevier, 2017, 1 (2), pp.65-73. ⟨10.1016/S2542-5196(17)30009-8⟩ Lancet Planetary Health, 2017, 1 (2), pp.65-73. ⟨10.1016/S2542-5196(17)30009-8⟩ Lancet Planetary Health (2542-5196) (Elsevier Sci Ltd), 2017-05, Vol. 1, N. 2, P. E65-E73 The Lancet Planetary Health, Vol 1, Iss 2, Pp e65-e73 (2017) |
| ISSN: | 2542-5196 |
| DOI: | 10.1016/S2542-5196(17)30009-8⟩ |
| Popis: | Summary Background Mycobacterium ulcerans infection is the third most common mycobacterial disease in the world after tuberculosis and leprosy. To date, transmission pathways from its environmental reservoir to humans are still unknown. In South America, French Guiana has the highest reported number of M ulcerans infections across the continent. This empirical study aimed to characterise the epidemiology of M ulcerans infection in French Guiana between 1969 and 2013. Methods Data were collected prospectively mainly by two dermatologists at Cayenne Hospital's dermatology department between Jan 1, 1969, and Dec 31, 2013, for age, date of diagnosis, sex, residence, location of the lesion, type of lesion, associated symptoms, and diagnostic method (smear, culture, PCR, or histology) for all confirmed and suspected cases of M ulcerans . We obtained population data from censuses. We calculated mean M ulcerans infection incidences, presented as the number of cases per 100 000 person-years. Findings 245 patients with M ulcerans infections were reported at Cayenne Hospital's dermatology department during the study period. M ulcerans infection incidence decreased over time, from 6·07 infections per 100 000 person-years (95% CI 4·46–7·67) in 1969–83 to 4·77 infections per 100 000 person-years (3·75–5·79) in 1984–98 and to 3·49 infections per 100 000 person-years (2·83–4·16) in 1999–2013. The proportion of children with infections also declined with time, from 42 (76%) of 55 patients in 1969–83 to 26 (31%) of 84 in 1984–98 and to 22 (21%) of 106 in 1999–2013. Most cases occurred in coastal areas surrounded by marshy savannah (incidence of 21·08 per 100 000 person-years in Sinnamary and 21·18 per 100 000 person-years in Mana). Lesions mainly affected limbs (lower limbs 161 [66%] patients; upper limbs 60 [24%] patients). We diagnosed no bone infections. Interpretation The decrease of M ulcerans infection incidence and the proportion of children with infections over a 45 year period in this ultra-peripheral French territory might have been mostly driven by improving living conditions, prophylactic recommendations, and access to health care. Funding Agence Nationale de la Recherche. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|