New Sesquiterpenoids from the Root of Guatteria multivenia
| Autor: | Alice M. Clark, David S. Pasco, Zhizhen Zhang, Larry A. Walker, Hala N. ElSohly, Melissa R. Jacob |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Staphylococcus aureus
Aporphines Stereochemistry Molecular Conformation Annonaceae Pharmaceutical Science DEPT Sesquiterpene Plant Roots Analytical Chemistry Inhibitory Concentration 50 chemistry.chemical_compound Alkaloids Anti-Infective Agents Candida albicans Peru Drug Discovery Aspartic Acid Endopeptidases Protease Inhibitors Nuclear Magnetic Resonance Biomolecular Antibacterial agent Pharmacology Plants Medicinal Molecular Structure biology Organic Chemistry Liriodenine biology.organism_classification Terpenoid Anti-Bacterial Agents Complementary and alternative medicine chemistry Phytochemical Cryptococcus neoformans Molecular Medicine Sesquiterpenes |
| Zdroj: | Journal of Natural Products. 65:856-859 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np0200717 |
| Popis: | A phytochemical investigation of the CHCl(3) fraction of an ethanol extract of the root of Guatteria multivenia furnished nine compounds, of which four are sesquiterpenes (1-4) and five are alkaloids (5-9). Of the four sesquiterpenes, two are new (1, 3), named guatterin A (1) and dihydromadolin-K (3), and two are known (2, 4), identified as madolin-K (2) and madolin-W (4). The five known alkaloids were identified as liriodenine (5), lysicamine (6), lanuginosine (7), guadiscine (8), and O-methylpallidine (9). All the known compounds were isolated from this species for the first time. Structures of the new compounds were determined by extensive NMR studies, including DEPT, COSY, HMQC, HMBC, and NOESY. Compound 7 showed weak inhibitory effect against Candida albicans secreted aspartic proteases (SAP) with IC(50) of 45 microg/mL. Compound 5 was found to have antimicrobial activity against C. albicans, Cryptococcusneoformans, Staphylococcus aureus, and methicillin-resistant S. aureus (MRS) with IC(50)/MIC values of 3.5/6.25, 2.0/12.5, 2.0/3.13, and 2.0/3.13 microg/mL, respectively. |
| Databáze: | OpenAIRE |
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