Haemodynamic effects of rocuronium bromide in adult cardiac surgical patients
| Autor: | William C. Tullock, Leonard L. Firestone, Kenneth P. Rothfield, Mark E. Hudson |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Pulmonary Circulation Cardiac output medicine.medical_specialty Mean arterial pressure Cardiac index Blood Pressure Anesthesia General Pulmonary Artery Intraoperative Period Heart Rate Internal medicine medicine Humans Androstanols Cardiac Output Rocuronium Pulmonary wedge pressure Aged Aged 80 and over Cardiopulmonary Bypass business.industry Hemodynamics Central venous pressure General Medicine Middle Aged Anesthesiology and Pain Medicine medicine.anatomical_structure Blood pressure Anesthesia Vascular resistance Cardiology Female business Neuromuscular Nondepolarizing Agents medicine.drug |
| Zdroj: | Canadian Journal of Anaesthesia. 45:139-143 |
| ISSN: | 1496-8975 0832-610X |
| DOI: | 10.1007/bf03013252 |
| Popis: | To measure the haemodynamic effects of rocuronium in adults undergoing cardiac surgery with cardiopulmonary bypass (CPB). Twenty patients undergoing elective cardiac surgical procedures with moderate hypothermic nonpulsatile bypass participated in this prospective, observational study. After anaesthetic induction, recovery from succinylcholine, and achievement of baseline haemodynamic stability, patients received 0.6 mg·kg−1 rocuronium as an initial rapid intravenous bolus. Maintenance dosing of 0.2 mg·kg−1 was continued for the remainder of the procedure, Haemodynamic measurements (heart rate, systemic arterial systolic, diastolic, and mean arterial pressure, pulmonary arterial systolic, diastolic, and mean pressure, pulmonary capillary wedge pressure, central venous pressure, and thermodilution cardiac output measurements) were obtained for the first five minutes after rocuronium administration, and subjects were observed for histamine-related symptoms. Central venous pressure decreased from baseline at two and five minutes after the rocuronium bolus, and mean pulmonary artery pressure decreased at five minutes. No changes were observed in heart rate, mean systemic arterial pressure, pulmonary capillary wedge pressure, cardiac index, stroke volume, systemic vascular resistance, or pulmonary vascular resistance, nor did any patient manifest any other histamine-related symptoms. The haemodynamic profile for a 0,6 mg·kg−1 bolus of rocuronium is acceptable for patients with cardiovascular disease. |
| Databáze: | OpenAIRE |
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