Extracardial Vasculopathy After Kawasaki Disease: A Long‐Term Follow‐up Study

Autor: Sanne M. Dietz, Carline E. Tacke, Eric de Groot, Irene M. Kuipers, Barbara A. Hutten, Taco W. Kuijpers, Maartje ten Berge, Maarten H. Biezeveld, Martijn Bruijn, Luçan C. Delemarre, Koert M. Dolman, Luc H.P.M. Filippini, Tom Hendriks, Dianne A.P.G.F. Maingay‐Visser, Jeroen G. Noordzij, Roos Nuboer, Frans B. Plötz, Lieke Rozendaal, Gavin W. ten Tusscher, Sander Starreveld, Jennifer J. Verhoeven, Nielske M. Weggelaar, Olivier Weijer, Peter de Winter
Přispěvatelé: Other departments, AII - Amsterdam institute for Infection and Immunity, General Paediatrics, ACS - Amsterdam Cardiovascular Sciences, Paediatric Cardiology, Epidemiology and Data Science, Paediatric Infectious Diseases / Rheumatology / Immunology
Rok vydání: 2016
Předmět:
Carotid Artery Diseases
Male
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
0302 clinical medicine
Risk Factors
Child
Ultrasonography
Coronary artery aneurysm
Coronary Aneurysm
Editorial
Echocardiography
Child
Preschool
cardiovascular system
Cardiology
Female
Cardiology and Cardiovascular Medicine
Vasculitis
Adult
medicine.medical_specialty
Adolescent
Long term follow up
Mucocutaneous Lymph Node Syndrome
Positive correlation
Young Adult
03 medical and health sciences
Internal medicine
Ultrasound
medicine
Humans
cardiovascular diseases
Kawasaki disease
business.industry
Siblings
Inflammatory Heart Disease
Editorials
carotid ultrasound
Infant
medicine.disease
Surgery
Increased risk
Peripheral Vascular Disease
Intima-media thickness
Case-Control Studies
long‐term follow‐up
Linear Models
business
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Journal of the American Heart Association, 5(7). Wiley-Blackwell
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
DOI: 10.1161/jaha.116.003414
Popis: Background Kawasaki disease ( KD ) is a pediatric vasculitis with coronary artery aneurysm ( CAA ) as a major complication. Controversy exists about cardiovascular risk later in life. The aim of our study was to evaluate whether KD patients are at increased risk, as assessed by carotid intima‐media thickness ( cIMT ). Methods and Results We measured cIMT over 15 years by B‐mode ultrasonography in KD patients during follow‐up and in unaffected controls (mostly siblings). A multilevel, repeated‐measures, linear mixed‐effects model was used to evaluate the association between KD and cIMT . A total of 319 patients with 528 measurements were compared with 150 controls. In KD patients, the mean cIMT was increased compared with controls (0.375 mm [95% CI 0.372–0.378 mm] versus 0.363 mm [95% CI 0.358–0.368 mm]; P cIMT of CAA ‐negative patients was 0.373 mm ( P CAA was 0.374 mm ( P CAA was 0.381 mm ( P CAA ‐negative participants started with an increased cIMT (+0.0193±0.0053 mm, P P =0.012). Patients with giant CAA showed a trend toward increased cIMT progression (0.0013±0.0007 mm/year, P =0.058). Conclusions We observed a positive correlation between cIMT and KD severity of coronary arteritis at the acute stage. Although initially increased, the cIMT in CAA ‐negative patients normalized at a later age. In contrast, patients with a history of KD complicated by giant CAA showed a trend toward persistently increased cIMT . These patients may need cardiovascular counseling and follow‐up beyond the heart.
Databáze: OpenAIRE
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