Differential challenges in salivary gland neoplasms
| Autor: | Nikola Zivkovic, Miloš Kostić, Milan Spasić, Dane Krtinić, Tijana Denčić, Maja Jovičić-Milentijević, Ana Cvetanovic, Milica Petrović, Miloš Trajković |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Proliferative index Adenoid cystic carcinoma Warthin Tumor salivary gland Biology ki67 medicine.disease Basal cell adenoma General Biochemistry Genetics and Molecular Biology Salivary duct carcinoma Pleomorphic adenoma stomatognathic diseases lcsh:Biology (General) Pleomorphism (cytology) Mucoepidermoid carcinoma immunohistochemistry medicine General Agricultural and Biological Sciences lcsh:QH301-705.5 neoplasm morphometry |
| Zdroj: | Archives of Biological Sciences, Vol 73, Iss 1, Pp 65-72 (2021) |
| ISSN: | 1821-4339 0354-4664 |
| DOI: | 10.2298/abs201201002z |
| Popis: | Salivary gland tumors are neoplasms characterized by a high level of pleomorphism and histological overlap. One tumor may contain several cell types; therefore, it is necessary to include immunohistochemical staining, as well as morphometric analysis of tumor cells as prerequisites for an appropriate diagnosis. Our research included 120 tumors, such as pleomorphic adenoma, Warthin tumor, basal cell adenoma, myoepithelioma, adenoid cystic carcinoma, mucoepidermoid carcinoma, salivary duct carcinoma, polymorphous low-grade carcinoma and myoepithelial carcinoma. The aim of the study was to differentiate benign and malignant tumors based on the characteristics of nuclei. The expression of Ki67 and the morphometric nuclear parameters ? area, perimeter, Feret diameter, integrated optical density, circularity, and roundness, were analyzed. It was observed that the Ki67 proliferative index was statistically significantly higher in malignant tumors (P |
| Databáze: | OpenAIRE |
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