Age-Specific Levels of Diabetes-Related GAD and IA-2 Antibodies in Healthy Children and Adults
| Autor: | Olga Kordonouri, Reinhard Hartmann, Thomas Danne, Anette Grüters-Kieslich, Mikael Knip |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Glutamate decarboxylase Population Antibodies Cohort Studies Endocrinology Antibody Specificity Internal medicine Diabetes mellitus medicine Humans Receptor-Like Protein Tyrosine Phosphatases Class 8 Child education Aged Aged 80 and over Protein Tyrosine Phosphatase Non-Receptor Type 1 Type 1 diabetes education.field_of_study biology Glutamate Decarboxylase business.industry Age Factors Radioimmunoassay Middle Aged medicine.disease Age specific Diabetes Mellitus Type 1 ROC Curve Child Preschool Reference values Pediatrics Perinatology and Child Health biology.protein Female Protein Tyrosine Phosphatases Antibody business |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 15 |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem.2002.15.1.47 |
| Popis: | Glutamic acid decarboxylase (GAD) and tyrosine phosphatase IA-2 antibody levels were measured in 375 healthy children and adults and in 187 children with newly diagnosed type 1 diabetes mellitus (DM). GAD antibody levels were determined by radioimmunoassay, and IA-2 antibody levels by immunoprecipitation. Healthy children had higher GAD antibody levels than adults (p < 0.001). The 98th percentile was 1.60 U/ml in children and 1.16 U/ml in adults. IA-2 antibody levels did not differ between these two cohorts. Children with DM had higher GAD and IA-2 antibody levels than healthy children (p |
| Databáze: | OpenAIRE |
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