Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19
| Autor: | Désirée Larenas-Linnemann, Jacques Reynes, Josep M. Antó, Juan Carlos Ivancevich, Nieves Pizarro Lozano, Vincent Le Moing, Torsten Zuberbier, Adrian R. Martineau, Susana C. Fonseca, Wienczyslawa Czarlewski, Frederico S. Regateiro, Ludger Klimek, Sanna Toppila-Salmi, Hak Jong Choi, Erik Melén, Arunas Valiulis, Piotr Kuna, Helga Kraxner, Cezmi A. Akdis, G. Walter Canonica, Yoshitaka Okamoto, Marek Jutel, Nikolaos G. Papadopoulos, Joaquim Mullol, Bilun Gemicioglu, Philip W. Rouadi, Hubert Blain, Guido Iaccarino, Bolesław Samoliński, Alessandro Fiocchi, Rafael de la Torre, Oliver Pfaar, Jean Bousquet, Aziz Sheikh, Yves Rolland, Tari Haahtela, João Fonseca, Hyun Ju Kim, Alvaro A. Cruz, Anna Bedbrook, Jean-Paul Cristol, Ioana Agache |
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| Přispěvatelé: | Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Bousquet, J., Czarlewski, W., Zuberbier, T., Mullol, J., Blain, H., Cristol, J. -P., De La Torre, R., Pizarro Lozano, N., Le Moing, V., Bedbrook, A., Agache, I., Akdis, C. A., Canonica, G. W., Cruz, A. A., Fiocchi, A., Fonseca, J. A., Fonseca, S., Gemicioglu, B., Haahtela, T., Iaccarino, G., Ivancevich, J. C., Jutel, M., Klimek, L., Kraxner, H., Kuna, P., Larenas-Linnemann, D. E., Martineau, A., Melen, E., Okamoto, Y., Papadopoulos, N. G., Pfaar, O., Regateiro, F. S., Reynes, J., Rolland, Y., Rouadi, P. W., Samolinski, B., Sheikh, A., Toppila-Salmi, S., Valiulis, A., Choi, H. -J., Kim, H. J., Anto, J. M., Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Taste
medicine.medical_treatment Oxytocin Severity of Illness Index [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity Antioxidants Transient receptor potential channel 0302 clinical medicine COVID-19 Testing [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Immunology and Allergy 030223 otorhinolaryngology TRPA1 Cation Channel Clinical Immunology − Letter to the Editor Desensitization (medicine) [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases musculoskeletal neural and ocular physiology food and beverages General Medicine 3. Good health Up-Regulation Cough challenge [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology Vomiting medicine.symptom 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit psychological phenomena and processes Diet therapy NF-E2-Related Factor 2 Immunology Pungent food TRPV1 Down-Regulation TRPV Cation Channels Inflammation Brassica TRAP-1 Nrf2 03 medical and health sciences Severity of illness medicine Clinical Immunology − Review Article Humans business.industry SARS-CoV-2 Broccoli COVID-19 Nutrients Pungent foods Oxidative Stress 030228 respiratory system nervous system Desensitization Immunologic business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Biomarkers |
| Zdroj: | International Archives of Allergy and Immunology International Archives of Allergy and Immunology, Karger, In press, ⟨10.1159/000514204⟩ |
| ISSN: | 1018-2438 1423-0097 |
| Popis: | International audience; In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies. |
| Databáze: | OpenAIRE |
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