Antibacterial prenylbenzoic acid derivatives from Anodendron formicinum
| Autor: | Paul-Keilah Lunga, Qin Xujie, Yun-Li Zhao, Xiao-Dong Luo, Xing-Wei Yang, Ya-Ping Liu, Jiang-Ling Li |
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| Rok vydání: | 2014 |
| Předmět: |
Stereochemistry
Microbial Sensitivity Tests Anodendron medicine.disease_cause Drug Discovery Escherichia coli medicine Pharmacology Bacteria Molecular Structure Plant Stems Apocynaceae biology Plant Extracts Chemistry General Medicine Benzoic Acid Antimicrobial biology.organism_classification Anti-Bacterial Agents Phytochemical Chemical constituents Mic values Antibacterial activity |
| Zdroj: | Fitoterapia. 92:238-243 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2013.12.001 |
| Popis: | A phytochemical investigation on the stems of Anodendron formicinum led to the isolation of eight prenylbenzoic acid derivatives. Three of these were new compounds, designated as formicinuosides A (1), B (2), and C (3). Their structures were elucidated on the basis of extensive spectroscopic analysis, as well as by comparison with the reported spectroscopic data. This is the first report of chemical constituents from A. formicinum and their antimicrobial activities. Among the isolated compounds, compounds 4,6 and 8 showed significant antibacterial activities against Providensia smartii with MIC values of 0.781 mu g/mL. Moreover, compound 8 showed remarkable antibacterial activity against Escherichia coli with MIC value of 0.781 mu g/mL. (C) 2013 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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