Effects of estradiol and progesterone on catecholamine turnover rates in discrete hypothalamic regions in ovariectomized rats
| Autor: | Charles A. Barraclough, Phyllis M. Wise, Naomi Rance |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Dopamine Hypothalamus Methyltyrosines Norepinephrine Endocrinology Arcuate nucleus Internal medicine medicine Animals Castration Progesterone Estradiol Chemistry Silastic Luteinizing Hormone Prolactin Rats alpha-Methyltyrosine Median eminence Ovariectomized rat Catecholamine Female Gonadotropin Follicle Stimulating Hormone hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Endocrinology. 108(6) |
| ISSN: | 0013-7227 |
| Popis: | Norepinephrine (NE) and dopamine (DA) activities were measured in several discrete brain areas (medial preoptic nucleus, suprachiasmatic nucleus, median eminence, and arcuate nucleus) in ovariectomized (OVX) and OVX steroidtreated rats. We wished to determine whether catecholamine (CA) mechanisms are involved in estradiol (E2)-induced LH surges and if amplification of such surges by progesterone (P)affects these CA systems. Animals were OVX, and 1 week later (day 0), groups were treated with Silastic capsules containing oilor an E2 solution (150 μg/ml in sesame oil). At 0900 h on day 2, E2-treated animals received Silastic capsules containing oil or P (50 mg/ml in oil). This steroid treatment results in physiologicalserum concentrations of both steroids. CA concentrations were determined by radioenzymatic assay in animals killed at 1000 or 1500 h on day 2 and in animals which were sacrificed 2 h after receiving a-methyl paratyrosine (400 mg/kg) at 1000 or 1500 h. Serum LH, FSH, PRL, E2, and P concentratio... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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