An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection
| Autor: | Diana Alejandra González, Vivian Garzón, Tatiana Pacheco, Daniela Ramírez, J. García, Rosa-Helena Bustos |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Drug Gram-negative bacteria medicine.drug_class media_common.quotation_subject Polymyxin 030106 microbiology Antibiotics Review Pharmacology medicine.disease_cause Biochemistry Microbiology 03 medical and health sciences Antibiotic resistance medicine Pharmacology (medical) colistin antimicrobial resistance General Pharmacology Toxicology and Pharmaceutics media_common biology business.industry multidrug-resistant (MDR) therapeutic drug monitoring (TDM) lcsh:RM1-950 Pathogenic bacteria extensive-drug resistant (XDR) biology.organism_classification Multiple drug resistance 030104 developmental biology Infectious Diseases lcsh:Therapeutics. Pharmacology pandrug-resistant (PDR) Colistin business medicine.drug |
| Zdroj: | Antibiotics Antibiotics, Vol 8, Iss 3, p 100 (2019) |
| ISSN: | 2079-6382 |
| Popis: | Antimicrobial resistance to antibiotic treatment has significantly increased during recent years, causing this to become a worldwide public health problem. More than 70% of pathogenic bacteria are resistant to at least one of the currently used antibiotics. Polymyxin E (colistin) has recently been used as a “last line” therapy when treating Gram-negative multi-resistant bacteria. However, little is known about these molecules’ pharmacological use as they have been discontinued because of their high toxicity. Recent research has been focused on determining colistimethate sodium’s pharmacokinetic parameters to find the optimal dose for maintaining a suitable benefit−risk balance. This review has thus been aimed at describing the use of colistin on patients infected by multi-drug resistant bacteria and the importance of measuring this drug’s plasma levels in such patients. |
| Databáze: | OpenAIRE |
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