Genetic Analysis of Influenza A/H3N2 and A/H1N1 Viruses Circulating in Vietnam from 2001 to 2006
| Autor: | Duc T. Dinh, Yugo Shobugawa, Hien T. Nguyen, Hiroshi Suzuki, Danjuan Li, Hang L. K. Nguyen, Mai T. Q. Le, Lien P. Huynh, Phuong Vu Mai Hoang, Huong Thi Thu Tran, Ha K. Nghiem, Yasushi Suzuki, Long T. Hoang, Makoto Nishikawa, Reiko Saito |
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| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
viruses Molecular Sequence Data Reassortment Orthomyxoviridae Neuraminidase Sequence Homology Hemagglutinin Glycoproteins Influenza Virus medicine.disease_cause H5N1 genetic structure Antigenic drift Evolution Molecular Viral Matrix Proteins Epitopes Viral Proteins Influenza A Virus H1N1 Subtype Virology Influenza Human Evolution of influenza Influenza A virus medicine Humans Antigens Viral Phylogeny Genetics biology Influenza A Virus H3N2 Subtype Genetic Drift virus diseases Antigenic shift Sequence Analysis DNA biology.organism_classification respiratory tract diseases Vietnam Viral evolution Reassortant Viruses |
| Zdroj: | Journal of Clinical Microbiology. 46:399-405 |
| ISSN: | 1098-660X 0095-1137 |
| Popis: | Influenza A virus has the ability to overcome immunity from previous infections through the acquisition of genetic changes. Thus, understanding the evolution of the viruses in humans is important for the surveillance and the selection of vaccine strains. A total of 30 influenza A/H3N2 viruses and 35 influenza A/H1N1 viruses that were collected in Vietnam from 2001 to 2006 were used to analyze the evolution of the hemagglutinin (HA), neuraminidase (NA), and matrix protein (M) genes. Phylogenetic analysis of individual gene segments revealed that the HA and the NA genes of the influenza A viruses evolved in a sequential way. However, the evolutionary pattern of the M gene proved to be nonlinear and was not linked with that of the HA and NA genes. Genetic drift in HA1 segments, especially in the antigenic sites of A/H3N2 viruses, occurred more frequently in A/H3N2 viruses than it did in A/H1N1 viruses. Two reassortants, one influenza A/H3N2 strain and one A/H1N1 strain, were found on the basis of the phylogenetic analysis of the three genes. While both genetic mutation and reassortment contributed to their evolution, the frequency of genetic changes and reassortment events differs between the two subtypes. As influenza viruses circulate throughout the year, we emphasize the importance of surveillance in tropical and subtropical zones, where the emergence of new strains may be detected earlier than it is in temperate zones. |
| Databáze: | OpenAIRE |
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