L'inactivation du chromosome x chez une vache porteuse d'une translocation x autosome
| Autor: | P. K. Basrur, P. C. Popescu, E. R. Reyes, N. A. Berepubo, L. E. L. Pinheiro |
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| Přispěvatelé: | Laboratoire de cytogénétique (UNCEIA/INRA), Institut National de la Recherche Agronomique (INRA), ProdInra, Migration |
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Male
Heterozygote medicine.medical_specialty X Chromosome Aneuploidy Chromosomal translocation [SDV.GEN] Life Sciences [q-bio]/Genetics Biology Translocation Genetic X-inactivation Dosage Compensation Genetic Genetics medicine Animals Molecular Biology Skewed X-inactivation X chromosome [SDV.GEN]Life Sciences [q-bio]/Genetics Dosage compensation Cytogenetics Karyotype General Medicine medicine.disease Molecular biology Chromosome Banding Karyotyping Cattle Female Biotechnology |
| Zdroj: | Genome Genome, NRC Research Press, 1992, 35, pp.667-675 |
| ISSN: | 0831-2796 1480-3321 |
| Popis: | The pattern of X chromosome inactivation in X autosome translocation carriers in a herd of Limousin–Jersey crossbred cattle was studied using the reverse banding technique consisting of 5-bromodeoxyuridine incorporation and acridine orange staining and autoradiography on cultures of solid tissues and blood samples exposed to tritiated thymidine. The late-replicating X chromosome was noted to be the normal X in strikingly high proportions of cells in cultures of different tissues from all translocation carriers. It is suggested that the predominance of cells in which the normal X is inactivated may be the result of a postinactivation selection process. Such a selection process during the prenatal life favouring cells in which the genes of the normal X chromosome remain unexpressed in translocation carrier females may be the mechanism that helps these conceptuses escape the adverse effects of functional aneuploidy. Based on the observation that the translocation carriers of this line of cattle are exclusively females and that there is a higher than expected rate of pregnancy loss, it is also postulated that the altered X chromosome may be lethal to all male conceptuses and to some of their female counterparts.Key words: X inactivation, X autosome translocation, bovine chromosomes, familial translocation. |
| Databáze: | OpenAIRE |
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