Adherence to Pre-exposure Prophylaxis in Black Men Who Have Sex with Men and Transgender Women in a Community Setting in Harlem, NY
| Autor: | Julie Franks, Justin Knox, Wafaa El-Sadr, F. S. Winterhalter, Yael Hirsch-Moverman, Paul W. Colson, Yingfeng Wu, Hugo Ortega |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Social Psychology Anti-HIV Agents New York HIV Infections Transgender Persons Transgender women Men who have sex with men Medication Adherence 03 medical and health sciences Pre-exposure prophylaxis 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) medicine Humans 030212 general & internal medicine Homosexuality Male 030505 public health business.industry Public health Public Health Environmental and Occupational Health medicine.disease Clinical trial Black or African American Health psychology Infectious Diseases Family medicine Community setting Female Pre-Exposure Prophylaxis 0305 other medical science business |
| Zdroj: | AIDS and behavior. 24(12) |
| ISSN: | 1573-3254 |
| Popis: | While oral pre-exposure prophylaxis (PrEP) has proven efficacious for HIV prevention, consistent use is necessary to achieve its intended impact. We compared effectiveness of enhanced PrEP (enPrEP) adherence support to standard of care (sPrEP) among Black MSM and TGW attending a community clinic in Harlem, NY. EnPrEP included peer navigation, in-person/online support groups, and SMS messages. Self-reported adherence over previous 30 days, collected in quarterly interviews, was defined as ≥ 57%. Crude and adjusted analyses examined factors associated with adherence. A total of 204 participants were enrolled and randomized; 35% were lost to follow-up. PrEP adherence was 30% at 12-months; no intervention effect was observed (p = 0.69). Multivariable regression analysis found that lower adherence was associated with low education and depressive symptoms. We found that an enhanced adherence intervention did not improve PrEP adherence. Findings point to the need for innovative methods to improve PrEP adherence among Black MSM and TGW. Clinical Trial Registration NCT02167386, June 19, 2014 |
| Databáze: | OpenAIRE |
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