Effects of Cinnamon (C. zeylanicum) Bark Oil Against Taxanes-Induced Damages in Sperm Quality, Testicular and Epididymal Oxidant/Antioxidant Balance, Testicular Apoptosis, and Sperm DNA Integrity

Autor:	Abdurrauf Yüce, Mehmet Güvenç, Saim Özdamar, Gaffari Türk, Fazile Canturk, Arzu Yay, Serpil Sarıözkan
Rok vydání:	2016
Předmět:	Male endocrine system Cancer Research medicine.medical_specialty Cinnamomum zeylanicum Paclitaxel medicine.medical_treatment Intraperitoneal injection Medicine (miscellaneous) Apoptosis DNA Fragmentation Docetaxel Biology Protective Agents medicine.disease_cause Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Testis Oils Volatile medicine Animals Testosterone Rats Wistar Sperm motility Epididymis 030219 obstetrics & reproductive medicine Nutrition and Dietetics urogenital system Malondialdehyde Spermatozoa Sperm Oxidative Stress medicine.anatomical_structure Endocrinology Oncology chemistry 030220 oncology & carcinogenesis DNA fragmentation Taxoids Biomarkers Oxidative stress
Zdroj:	Nutrition and Cancer. 68:481-494
ISSN:	1532-7914 0163-5581
DOI:	10.1080/01635581.2016.1152384
Popis:	The aim of this study was to investigate whether cinnamon bark oil (CBO) has protective effect on taxanes-induced adverse changes in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular apoptosis, and sperm DNA integrity. For this purpose, 88 adult male rats were equally divided into 8 groups: control, CBO, docetaxel (DTX), paclitaxel (PTX), DTX+PTX, DTX+CBO, PTX+CBO, and DTX+PTX+CBO. CBO was given by gavage daily for 10 weeks at the dose of 100 mg/kg. DTX and PTX were administered by intraperitoneal injection at the doses of 5 and 4 mg/kg/week, respectively, for 10 weeks. DTX+PTX and DTX+PTX+CBO groups were treated with DTX during first 5 weeks and PTX during next 5 weeks. DTX, PTX, and their mixed administrations caused significant decreases in absolute and relative weights of all reproductive organs, testosterone level, sperm motility, concentration, glutathione level, and catalase activity in testicular and epididymal tissues. They also significantly increased abnormal sperm rate, testicular and epididymal malondialdehyde level, apoptotic germ cell number, and sperm DNA fragmentation and significantly damaged the histological structure of testes. CBO consumption by DTX-, PTX-, and DTX+PTX-treated rats provided significant ameliorations in decreased relative weights of reproductive organs, decreased testosterone, decreased sperm quality, imbalanced oxidant/antioxidant system, increased apoptotic germ cell number, rate of sperm with fragmented DNA, and severity of testicular histopathological lesions induced by taxanes. In conclusion, taxanes cause impairments in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular histopathological structure, and sperm DNA integrity, and long-term CBO consumption protects male reproductive system of rats.
Databáze:	OpenAIRE
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