Comparison of the effects of preoperative melatonin or vitamin C administration on postoperative analgesia
| Autor: | Murat Türkeün Ilgınel, Hakkı Ünlügenç, Feride Karacaer, Merthan Tunay, Demet Lafli Tunay, Ebru Biricik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Nausea Sedation Analgesic vitamin C Ascorbic Acid Anesthesia General Placebo Antioxidants morphine consumption Melatonin 03 medical and health sciences 0302 clinical medicine Double-Blind Method 030202 anesthesiology Abdomen Humans Medicine Prospective Studies Pain Postoperative lcsh:R5-920 business.industry Central Nervous System Depressants General Medicine postoperative analgesia Middle Aged Analgesics Opioid Anesthesia Postoperative Nausea and Vomiting Vomiting Morphine Female medicine.symptom business lcsh:Medicine (General) 030217 neurology & neurosurgery Research Article medicine.drug Abdominal surgery |
| Zdroj: | Bosnian Journal of Basic Medical Sciences (2019) Bosnian Journal of Basic Medical Sciences |
| Popis: | The analgesic benefit of melatonin and vitamin C as primary or adjuvant agents has been reported in various studies; however, their analgesic effects in the treatment of postoperative pain remain unclear. Thus, we aimed to evaluate the effect of single preoperative dose of oral melatonin or vitamin C administration on postoperative analgesia. In this study, we recruited 165 adult patients undergoing elective major abdominal surgery under general anesthesia. Patients were randomly divided into three equal (n = 55) groups. One hour before surgery, patients received orally melatonin (6 mg) in group M, vitamin C (2 g) in group C, or a placebo tablet in group P. Pain, sedation, patient satisfaction, total morphine consumption from a patient-controlled analgesia device, supplemental analgesic requirement, and the incidence of nausea and vomiting were recorded throughout 24 h after surgery. The mean pain score and total morphine consumption were found significantly lower in both M and C groups compared with group P (p < 0.001). There were no significant differences between group M and C with respect to pain scores (p = 0.117) and total morphine consumption (p = 0.090). Patients requested less supplemental analgesic and experienced less nausea and vomiting in groups M and C compared with group P. In conclusion, preoperative oral administration of 6 mg melatonin or 2 g vitamin C led to a reduction in pain scores, total morphine consumption, supplemental analgesic requirement, and the incidence of nausea and vomiting compared with placebo. |
| Databáze: | OpenAIRE |
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