Translational Regulation of Cancer Metastasis
| Autor: | Shyamala Maheswaran, Douglas S. Micalizzi, Richard Y. Ebright, Daniel A. Haber |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Epithelial-Mesenchymal Transition Carcinogenesis Cell Survival Cell Biology medicine.disease_cause Article Metastasis 03 medical and health sciences 0302 clinical medicine Cell Movement Transforming Growth Factor beta Neoplasms Translational regulation medicine Tumor Microenvironment Humans Neoplasm Metastasis Messenger RNA Neovascularization Pathologic TOR Serine-Threonine Kinases Translation (biology) medicine.disease Phenotype Neoplasm Proteins 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Protein Biosynthesis Cancer cell Cancer research Tumor Hypoxia Tumor Escape |
| Zdroj: | Cancer Res |
| ISSN: | 1538-7445 |
| Popis: | Deregulation of the mRNA translational process has been observed during tumorigenesis. However, recent findings have shown that deregulation of translation also contributes specifically to cancer cell spread. During metastasis, cancer cells undergo changes in cellular state, permitting the acquisition of features necessary for cell survival, dissemination, and outgrowth. In addition, metastatic cells respond to external cues, allowing for their persistence under significant cellular and microenvironmental stresses. Recent work has revealed the importance of mRNA translation to these dynamic changes, including regulation of cell states through epithelial-to-mesenchymal transition and tumor dormancy and as a response to external stresses such as hypoxia and immune surveillance. In this review, we focus on examples of altered translation underlying these phenotypic changes and responses to external cues and explore how they contribute to metastatic progression. We also highlight the therapeutic opportunities presented by aberrant mRNA translation, suggesting novel ways to target metastatic tumor cells. |
| Databáze: | OpenAIRE |
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